The Relationship of Balance, Proprioception, Coordination, and Reaction Time Measurements With Motion Sickness Severity in Individuals With Motion Sickness: A Cross-Sectional Study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 41
- 主要终点
- Motion Sickness Severity (Graybiel Score)
研究概览
简要总结
Background: Motion sickness (MS) is a common syndrome characterized by autonomic and behavioral symptoms, such as nausea and dizziness, resulting from exposure to motion stimuli. Its pathophysiology is closely linked to sensory conflict and postural instability theories. While previous studies suggest that postural control, proprioception, and reaction times are affected in individuals susceptible to MS, there is a lack of comprehensive, comparative research evaluating all these parameters concurrently within the same cohort using standardized methods. Objective: This study aims to systematically measure balance, proprioceptive sensitivity, coordination, and reaction time parameters, and quantitatively analyze their relationship with motion sickness severity. Methodology: In this prospective, cross-sectional study, at least 41 participants aged 18-40 with motion sickness will be recruited. Participants will undergo motion sickness susceptibility and severity grading using the Motion Sickness Susceptibility Questionnaire Short Form (MSSQ-SF) and the Graybiel Scale. Objective assessments will include static and dynamic balance testing (ProKin®), knee joint position sense (Clinometer app), manual dexterity and dynamic balance coordination (Nine-Hole Peg Test, Tandem Walk, Romberg Test), and upper/lower extremity reaction time measurements (BlazePod system).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Individuals aged between 18 and 40 years.
- •Diagnosed with motion sickness according to the Motion Sickness -Susceptibility Questionnaire Short Form (MSSQ-SF).
- •Normal hearing acuity.
- •No history of acute or chronic vestibular disease, other than motion sickness.
- •Normal or corrected-to-normal vision.
- •Adequate physical capability to fully perform the measurement protocols, including balance, proprioception, coordination, and reaction time tests.
排除标准
- •Presence of any physical or orthopedic problem that could interfere with testing.
- •History of acute or chronic instability, unsteadiness, or vertigo.
- •Severe visual impairment.
- •History of prior ear surgery.
- •Presence of any neurological condition or disorder.
- •History of migraines.
- •Current use of medications that could affect balance or vestibular function (e.g., vestibular suppressants, sedatives).
- •Use of alcohol or psychoactive substances within the last 48 hours prior to testing.
结局指标
主要结局
Motion Sickness Severity (Graybiel Score)
时间窗: 1 hour
Used to grade the clinical severity of acute motion sickness symptoms (including nausea, cold sweating, increased salivation, and dizziness) following a randomized chair-rotation provocation protocol. 0 (Minimum) to 50 points (Maximum). Higher scores indicate greater symptom severity, representing a worse clinical outcome (scores of 16 or above designate frank sickness).
次要结局
未报告次要终点
研究者
Yunus Emre Tutuneken
Dr. Assistant Professor
Istinye University