Cardiovascular And Metabolic Risk After Arthroplasty: the CAMERA Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 152
- 试验地点
- 1
- 主要终点
- Aortic pulse wave velocity at 5 years after arthroplasty
研究概览
简要总结
Osteoarthritis is a chronic joint disease that lacks curative therapy. Epidemiological studies show increase in the burden of disease. Total joint arthroplasty is one of the best treatment options for end-stage osteoarthritis. However, the specific effects of total joint arthroplasty on cardiovascular risk and metabolic profile are largely unknown. The aim of this project is to elucidate how hip and knee total joint arthroplasty impacts cardiovascular risk and metabolomic profile in comparison with general population. We hypothesize that arthroplasty decreases pain, systemic inflammation levels and increases functional status that all lead to decreased metabolic and cardiovascular risk.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Aortic pulse wave velocity at 5 years after arthroplasty
时间窗: 5 years
5 years after the beginning of study for control group; measurements are done using the Sphygmocor device.
次要结局
- Changes in low-molecular weight metabolites(5 years)
- Metabolic syndrome risk score(5 years)
- Augmentation index(5 years)
- Central diastolic blood pressure(5 years)
- Composite of cardiovascular clinical events(5 years)
- Oxidized LDL-cholesterol(5 years)
- Hospital for Special Surgery knee score(5 years)
- Central pulse pressure(5 years)
- Leptin levels(5 years)
- Central systolic blood pressure(5 years)
- Oxidative stress index(5 years)
- Harris Hip score or Hospital for Special Surgery Knee score(5 years)
- Adiponectin level(5 years)
- SF-36(5 years)
研究者
Kaspar Tootsi
Orthopedic research fellow
University of Tartu