Prospective Genetic Study in Patients With Ovarian Insufficiency
试验速览
- 阶段
- 不适用
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- Genotype
研究概览
简要总结
genetic screening and etiological analysis was conducted on patients with ovarian insufficiency and decline in ovarian reserve. All patients were enrolled in the IVF-treated and non-IVF-treated groups, followed up for long-term treatment outcomes and genomic screening.
详细描述
The cause of ovarian insufficiency and decline in ovarian reserve are not clear, but most researchers think the probable causes are mainly three aspects: chromosomal abnormalities, genetic factors and autoimmune diseases，But the majority of patients with normal chromosome karyotype analysis. The screening of pathogenic genes in patients with normal karyotype is the focus of current premature ovarian insufficiency(POI) and decline in ovarian reserve(DOR) etiology, to further explain the pathogenesis of patients, improve the diagnosis of those diseases and Clinical treatment.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Patients diagnosed as "premature ovarian insufficiency", "diminished ovarian reserve", "primary amenorrhea", " ovarian dysgenesis", " repeated implantation failure"
排除标准
- •To rule out polycystic ovary syndrome（PCOS）, iatrogenic factors (such as surgery, radiotherapy and chemotherapy, etc.) lead to premature ovarian insufficiency in patients
结局指标
主要结局
Genotype
时间窗: 1/4/2018-24/12/2020
Measure the genotype by genome-wide sequencing of exomes(WES) in subjects.
次要结局
- Neonatal weight(1/4/2018-24/12/2020)
- Endometrial thickness(1/4/2018-24/12/2020)
- Dimensions of uterus(1/4/2018-24/12/2020)
- Live birth rate(1/4/2018-24/12/2020)
- Antral follicle count(1/4/2018-24/12/2020)