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临床试验/NCT05322278
NCT05322278已完成不适用

Obstetric Outcomes After Double Embryo Transfer in Intracytoplasmic Sperm Injection

Assiut University1 个研究点 分布在 1 个国家目标入组 927 人开始时间: 2022年3月30日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
927
试验地点
1
主要终点
Live birth

研究概览

简要总结

Aim ; to compare obstetric outcomes in relation to number of embryo transfer in ICSI

详细描述

Assisted reproductive technology with intracytoplasmic sperm injection (ICSI) and IVF is becoming an international direction for couples struggling with infertility. The increasing popularity and frequency of these techniques and the data generated from it has given us a better overview of the efficacy, consequences and costs of these techniques.

The aim of assisted reproductive technology (ART) is to achieve pregnancy while decreasing the risk of multiple gestations. When compared with elective single embryo transfer (SET), double embryo transfer (DET) demonstrates a superior pregnancy and live birth rate with a significantly higher risk of multiple gestations. The high frequency of multiple births is the main factor which leads to adverse outcome in IVF/intracytoplasmic sperm injection (ICSI) treatment. Transfer of two embryos does not diminish the chance of a birth when compared with three embryo transfer. How would be the obstetric outcome in pregnancies resulting from DET in IVF/ICSI cycles.

Despite achieving a higher pregnancy rates, DET in ART leads to an increase in multiple gestation pregnancies, which are associated with increased both maternal and neonatal morbidity and mortality.

Twin pregnancies have a higher incidence of preterm cesarean sections , admissions to the neonatal intensive care unit (NICU), and other maternal complications, when compared with singleton pregnancies. Twin pregnancies have a higher incidence of preterm cesarean sections , admissions to the neonatal intensive care unit (NICU), and other maternal complications, when compared with singleton pregnancies.

Most patients prefer to have two embryos transferred, due to financial considerations being the main reason.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Retrospective

入排标准

性别
Female
接受健康志愿者

入选标准

  • all patients subjected with ICSI pregnancy

排除标准

  • incomplete data

结局指标

主要结局

Live birth

时间窗: 1 year

Comparison

次要结局

  • Rate of admission to NICU(1 year)
  • Rate of Clinical pregnancy(1 year)
  • Rate of chemical pregnancy(1 year)
  • Rate of neonatal morbidities and mortalities in single embryo transfer versus double embryo transfer(1 year)
  • Rate of miscarriage(1 year)
  • Rate of multiple pregnancies(1 year)
  • Rate of PPROM(1 year)
  • Rate of preterm(1 year)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Ahmed Shehata Mohamed Ismail

Faculty of medicine, Assiut University, 71515 Assiut, Egypt

Assiut University

研究点 (1)

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