Brain Stimulation Effects on Cognitive Task Performance
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Sternberg Memory Task (Reaction Time)
研究概览
简要总结
The purpose of this study is to determine optimal task design parameters for the measurement of transcranial magnetic stimulation (TMS) effects on cognition.
详细描述
Transcranial magnetic stimulation (TMS) is a non-invasive form of brain stimulation that relies on rapidly changing magnetic fields to influence neuronal firing rates. TMS can be used to temporarily inhibit or enhance the firing of populations of neurons located in the cerebral cortex. TMS-induced cortical inhibition versus enhancement is increasingly being used as a tool for exploring brain-behavior relationships and for improving cognitive functioning in people experiencing cognitive deficits due to neuropsychiatric illness (e.g., dementia and schizophrenia). However, important and unresolved methodological issues in this field concern the optimal design of cognitive tasks for TMS stimulation protocols. The purpose of this study is to determine optimal design protocols for online TMS studies of cognitive processes involved in attention, learning, and memory. Research participants will complete cognitive tasks while active versus sham (i.e., non-stimulating) TMS is applied to the brain. A factorial design will be used to determine the combination of task and TMS parameters (i.e., device settings) that produce the most robust and reliable behavioral effects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Single (Participant)
盲法说明
Participants are blinded to TMS therapy, sham control
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Right-handed
- •Fluent in English
排除标准
- •History of seizures or epilepsy
- •Family history of epilepsy
- •Significant medical or neurological diagnoses
- •History of common headache or migraine
- •History of common or recent syncope
- •History of moderate/severe, multiple mild, or past 12 months head injury
- •History of psychiatric, psychological, or neurodevelopmental disorder
- •History of alcohol or recreational drug abuse or dependence
- •Current visual or hearing difficulties that interfere with cognitive testing
- •History of cochlear implants
- •Current pregnancy
- •History of metal in the head or neck (except braces and fillings)
- •Current non-removable piercings in the neck or head
- •History of implanted neurostimulator
- •History of cardiac pacemaker or intracardiac lines
- •History of medication infusion device
- •Current use of medications that increase the excitability of the brain
- •History of problems with TMS or MRI procedures
- •History of EEG for suspected epilepsy
- •Alcohol or recreational drug use in the 48 hours prior to TMS
- •Inadequate sleep in the 48 hours prior to TMS
- •Headache or feeling faint in the 24 hours prior to TMS.
研究组 & 干预措施
Active TMS
Repetitive TMS for the brain
干预措施: Transcranial Magnetic Stimulation (Device)
Sham TMS
Scalp stimulation that does not affect the brain.
干预措施: Transcranial Magnetic Stimulation (Device)
结局指标
主要结局
Sternberg Memory Task (Reaction Time)
时间窗: Single study appointment. 1 hour. There will be no follow up.
Mean item reaction time on a computerized Sternberg memory task.
Sternberg Memory Task (Accuracy)
时间窗: Single study appointment. 1 hour. There will be no follow up.
Mean item accuracy on a computerized Sternberg memory task.
次要结局
未报告次要终点