NCT01552460已完成不适用
Brain Genomics Superstruct Project
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 61
- 试验地点
- 1
- 主要终点
- Neuroimaging phenotype
研究概览
简要总结
The purpose of this study is to explore the effects of genes and genetic variation on brain structure and function. Investigators at Harvard plan to explore the relationship between candidate genes that affect cognitive performance and brain structure/function. Since brain phenotypes reflect more proximal sequelae of gene activity, neuroimaging measures may show greater sensitivity than cognitive performance to measure gene effects.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 13 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •13 years or older
- •Subject must have a current DSM-IV diagnosis of high functioning ASD, based on past evaluations at the Bressler Clinic.
- •Subjects must have a level of understanding sufficient to communicate intelligently with the investigator and study coordinator, and to cooperate with all tests and examinations required by the protocol.
- •Each subject must understand the nature of the study. The subject must sign an IRB approved informed consent.
排除标准
- •IQ < 70 bassed on evaluation in the Bressler Clinic.
- •Contraindication to MRI including presence of metal or surgical devices (plates, implants, braces or other items).
- •Neuropsychiatric conditions (such as dementia) which sufficiently impair cognition such that a surrogate consent would be required.
- •Neurological disorders associated with gross brain pathology (other than atrophy), e.g., stroke, tumors, or demyelinating diseases.
结局指标
主要结局
Neuroimaging phenotype
时间窗: 1 day
次要结局
未报告次要终点
研究者
Gagan Joshi
Clinical Investigator, Clinical and Research Program in Pediatric Psychopharmacology and Adult ADHD
Massachusetts General Hospital
研究点 (1)
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