The Effect of D-cycloserine on Fear Learning and Extinction
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- change in BOLD-signal during a fear conditioning task
研究概览
简要总结
The present study investigates the effect of d-cycloserine on learning and unlearning of fear in healthy humans and its underlying effect on the amygdala.
As a second objective, the effect of genotype on fear learning will be studied.
详细描述
A growing body of evidence suggests that the extinction of fear is mediated by the N-methyl-D-aspartate (NMDA) receptor activity in the basolateral amygdala. Intra-amygdala infusions of antagonists of this glutamate receptor in small animals (eg: rats, mice) have demonstrated a blockage of fear acquisition and extinction. Agonists, on the other hand, facilitate conditioned fear extinction.
The animal studies are all based on the simple fear learning paradigm of conditioning. However, it is not clear that human anxiety disorders are based on prior conditioning encounter. Therefore it is important to disentangle the effect of DCS on acquisition and extinction in the context of a simple learning paradigm, particular its effect on the human amygdala.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •No axis I diagnosis compatible with the DSM-IV by means of a structured diagnostic interview
- •Right-handed
排除标准
- •Current psychopharmacological or psychological treatment.
- •The presence of a physical/medical condition that may interfere with the study.
- •A contraindication for the use of DCS
- •Pacemaker, medication pump (such as insulin pump), hearing aid, removable prosthodontics
- •Metal in or on body (such as acupuncture needles, artificial limbs, stents, metal splints, clips, implanted electrodes, tattoos, or piercings)
研究组 & 干预措施
d-Cycloserine Acquisition
d-Cycloserine will be given on day1, before acquisition
干预措施: d-Cycloserine (Drug)
d-Cycloserine Acquisition
d-Cycloserine will be given on day1, before acquisition
干预措施: Saliva sample (Genetic)
d-Cycloserine Acquisition
d-Cycloserine will be given on day1, before acquisition
干预措施: Functional neuroimaging (fMRI) (Other)
d-Cycloserine Extinction
d-Cycloserine will be administered on day2, before extinction
干预措施: d-Cycloserine (Drug)
d-Cycloserine Extinction
d-Cycloserine will be administered on day2, before extinction
干预措施: Saliva sample (Genetic)
d-Cycloserine Extinction
d-Cycloserine will be administered on day2, before extinction
干预措施: Functional neuroimaging (fMRI) (Other)
Placebo
A placebo pill will be administered on day1 and 2
干预措施: Lactose pill (Drug)
Placebo
A placebo pill will be administered on day1 and 2
干预措施: Saliva sample (Genetic)
Placebo
A placebo pill will be administered on day1 and 2
干预措施: Functional neuroimaging (fMRI) (Other)
结局指标
主要结局
change in BOLD-signal during a fear conditioning task
时间窗: t0, t+24, t+48
Subjects will participate in a 3-day experiment. Day1 (t0): Acquisition Day2 (T+24): extinction Day3 (T+48): re-exposure
次要结局
未报告次要终点