NL-OMON53291尚未招募不适用
Exercise intolerance in long-chain fatty acid oxidation disorders - EXCITE LcFAOD
Amsterdam UMC0 个研究点目标入组 50 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 50
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •LC-FAOD patients:
- •- Men and women (age >=18 years) with a confirmed diagnosis of carnitine
- •palmitoyltransferase 2 (CPT2) deficiency, Carnitine-acylcarnitine translocase
- •(CACT) deficiency, Mitochondrial Trifunctional protein (MTP) deficiency,
- •Very-long-chain acyl-CoA dehydrogenase (VLCAD) deficiency or Long-chain
- •3-hydroxyacyl-CoA dehydrogenase (LCHAD) deficiency.
- •Healthy control subjects:
- •- Healthy men and women age >= 18 years
排除标准
- •-LcFAOD patients: - Pregnancy - Recent acute myocardial infarction (>6
- •months prior to inclusion) - Uncontrolled arrhythmia/severe conduction disorder
- •causing hemodynamic compromise - Implantable pacemaker or other cardiac device
- •with complete ventricular pacing - Uncontrolled heart failure with hemodynamic
- •compromise - Uncontrolled hypertension (Systolic Blood Pressure >150 mmHg
- •and Diastolic Blood Pressure > 100 mmHg on repeated measurements) - Active
- •infection, anemia, severe renal dysfunction (estimated Glomerular filtration
- •rate <30 ml/min/1,73m2), or other chronic disease likely to significantly
- •impact exercise performance - History of severe asthma or chronic obstructive
- •pulmonary disease - Active use of medication likely to affect exercise
- •tolerance Healthy control subjects: - All abovementioned exclusion criteria for
- •LcFOAD patients - History of smoking - History of asthma, chronic obstructive
- •pulmonary disease, heart failure, heart surgery, heart rhythm disorders or
- •congenital heart diseases - Chronic illness (including orthopedic,
- •endocrinological, hematological, malignant, gastrointestinal, neurological,
- •muscle or inflammatory disorders) likely to significantly impact on exercise
- •performance - > 6 alcohol units per day or >14 alcohol units per week
研究者
相似试验
招募中
不适用
Exercise Intolerance Study in Long Chain Fatty Acid Oxidation DisordersLong-chain Fatty Acid Oxidation DisordersNCT05924555Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)50
已完成
不适用
Fatty Acid Induced Oxidative Stress: its role in preventing hypoglycemiao condition, healthy personISRCTN85121743Academic Medical Centre (AMC) (Netherlands)6
招募中
2 期
Investigation of mechanisms involved in exercise intolerance in patients with long-CovidRBR-7kyk2wyDisciplina de Pneumologia da Universidade Federal de São Paulo
已完成
不适用
Metabolism of long-chain polyunsaturated fatty acids and oxylipinsPrevention of civilization diseasesDRKS00011199niversität HannoverInstitut für Lebensmittelwissenschaft und Humanernährung15
已完成
不适用
Maximal fat oxidation during exercise: impact of nutritional status and exhaustioNL-OMON49381Wageningen Universiteit40