NL-OMON48095已完成不适用
euromuscular model for MND: Quantifying the effect of motor neuron disease on neural and non-neural properties of the lower limbs - Neuromuscular model for MND
niversitair Medisch Centrum Utrecht0 个研究点目标入组 300 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 300
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •1. a. MND patients: definite, probable, probable-laboratory supported or
- •possible ALS according to the El Escorial criteria (Brooks, 2000),
- •PMA or PLS.
- •b. Control subjects: no diagnosis of MND or ALS mimics and age- and
- •gender-matched to
- •patient groups, intact physical ability to take part in the
- •experiment.
- •c. Asymptomatic carriers: carriers of MND-related gene mutations with
- •no neurological
- •symptoms associated with MND.
- •2. Age:18 and older
- •3. Capable of performing active tests with their right hand; muscle strength
- •should be above 3 on
- •the medical research council (MRC) scale27.
- •4. Capable of thoroughly understanding the study information given; has signed
- •the informed
排除标准
- •Exclusion criteria are for all participants:
- •1. a history of major head trauma or other neurological conditions that could
- •affect cognition,
- •2. alcohol dependence syndrome, current use of neuroleptic medications or high
- •psychoactive medication.
- •3. History of reaction or allergy to recording environments, equipment and the
- •recording gels.
- •4. Tracheostomy, tracheostomal ventilation of any type, (non)-invasive
- •ventilation.
- •5. Pregnancy.
- •Further exclusion criteria for healthy controls and asymptomatic carriers:
- •6. History of neuromuscular, neurological or active psychiatric disease
- •Further exclusion criteria for patients:
- •7. The presence of any active psychiatric disease, and any medical condition
- •associated with
- •neuropathy (e.g. diabetes).
- •8. Any history or presence of brain injury, epilepsy, psychiatric illness and
- •other cerebral disease.
- •9. Any intoxication or medication known to have an association with motor
- •neuron dysfunction,
- •which might confound or obscure the diagnosis of MND.
研究者
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