Autophagy/Apoptosis Balance During Pregnancy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 97
- 试验地点
- 1
- 主要终点
- Potential autophagy induction activity in all groups
研究概览
简要总结
The object of this study is to assess the intra- and inter-individual variability of apoptosis and autophagy activities in women during pregnancy: 1 / in women with a normal pregnancy and 2 / in pregnant women particularly at risk of complications.
The study investigators hypothesize that there would be an intra-trophoblastic dialogue between the mechanisms of autophagy and apoptosis, the promotion of one partially inhibiting the other. The increase in trophoblastic autophagy during pregnancy could thus constitute an anti-apoptosis defense phenomenon, the exhaustion of which would lead to cellular apoptosis and to pathogenic consequences when it devastates the syncytiotrophoblast.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Patients followed at the CHU Nimes prior to 33 weeks gestation who give birth at the hospital
- •The patient must have given their free and informed consent and signed the consent form
- •The patient must be a member or beneficiary of a health insurance plan
排除标准
- •The subject is participating in a category 1 interventional study associated with a medication, or is in a period of exclusion determined by a previous study
- •The subject refuses to sign the consent
- •It is impossible to give the subject informed information
- •The patient is under safeguard of justice or state guardianship
- •Multiple pregnancy
结局指标
主要结局
Potential autophagy induction activity in all groups
时间窗: Delivery plus or minus 2 weeks (Month 6)
Microtubule-associated protein 1A/1B-light chain 3 fluorescence ratio
次要结局
- Autophagy kinetics between groups(Delivery plus or minus 2 weeks (Month 6))
- Placental Growth Factor in each group(Delivery plus or minus 2 weeks (Month 6))
- Renal function(Delivery plus or minus 2 weeks (Month 6))
- Whole blood count(Delivery plus or minus 2 weeks (Month 6))
- Fibrin levels(Delivery plus or minus 2 weeks (Month 6))
- Inflammation(Delivery plus or minus 2 weeks (Month 6))
- Activated partial thromboplastin time(Delivery plus or minus 2 weeks (Month 6))
- Fibrinogen level(Delivery plus or minus 2 weeks (Month 6))
- Type of autophagy inhibition per patient in all groups(Delivery plus or minus 2 weeks (Month 6))
- Apoptosis kinetics between groups(Delivery plus or minus 2 weeks (Month 6))
- Soluble fms-like tyrosine kinase-1(Delivery plus or minus 2 weeks (Month 6))
- Acquired thrombophilia(Delivery plus or minus 2 weeks (Month 6))
- Prothrombin time(Delivery plus or minus 2 weeks (Month 6))
- Thrombin generation time(Day 0)
- Potential apoptosis induction activity in all groups(Delivery plus or minus 2 weeks (Month 6))
- Inter- and intra-individual apoptosis/autophagy ratio in all groups(Delivery plus or minus 2 weeks (Month 6))
- Constitutive thrombophilia(Day 0)
- fetal haemoglobin(Delivery plus or minus 2 weeks (Month 6))