Effects of Dexmedetomidine on Delirium After Living Donor Renal Transplantation in Adult Patients
试验速览
- 阶段
- 4 期
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Postoperative Delirium
研究概览
简要总结
Delirium, an acute change in mental status, is a serious medical complication among hospitalized patients. Syndrome of delirium involves agitation, sleep disturbance, affective disorders and cognitive disruptions.
One vulnerable period for developing delirium is in the postoperative days. Postoperative delirium often initiates a cascade of adverse consequences including an increase in length of stay and hospital costs, and greater mortality. The investigators have observed that the incidence of postoperative delirium in patients after renal transplantation is about 20-30% in our hospital.
Several studies have revealed that dexmedetomidine, as a widely used sedative during anesthesia, can decrease the incidence of postoperative delirium after cardiac surgery. The investigators aim to examine whether administration of dexmedetomidine can reduce postoperative delirium after living donor renal transplantation in adult patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 59 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age > 17 and < 60 years;
- •American Society of Anesthesiology (ASA) I-III;
- •admitted for living donor renal transplantation.
排除标准
- •Patients with a history of drug abuse;
- •preoperative history of schizophrenia, epilepsy, parkinsonism, use of cholinesterase inhibitor, inability to communicate in the preoperative period (coma, profound dementia, or language barrier).
研究组 & 干预措施
Dexmedetomidine
Dexmedetomidine ivpump 0.2ug/kg/h during living donor renal transplantation.
干预措施: Dexmedetomidine (Drug)
Saline
Saline ivpump 0.2ug/kg/h during living donor renal transplantation.
干预措施: Saline (Drug)
结局指标
主要结局
Postoperative Delirium
时间窗: Postoperative day 1-7.
次要结局
未报告次要终点
研究者
Tao Zhang
Tao Zhang
First Affiliated Hospital, Sun Yat-Sen University