Pharmacokinetic Assessment of Acute Ingestion of Different Forms of Creatine
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 13
- 主要终点
- Examine creatine vs. creatine nitrate supplementation by assessing body composition
研究概览
简要总结
The purpose of this study is to examine the pharmacokinetics of creatine nitrate supplementation.
详细描述
Creatine nitrate contains several nutrients that may increase anaerobic exercise performance. Theoretically, dietary supplementation of creatine nitrate during resistance training can improve the quality of training leading to greater changes in strength, power and fat free mass. Endothelial function measured by flow-mediated dilation (FMD), a non-invasive vascular health parameter that can be measured via ultrasonography, is a predictor of cardiovascular disease risk which precedes traditional risk markers. Diet, physical activity and pharmaceutical interventions can all impact vascular function and health. The purpose of this study is to determine the acute vascular response of creatine nitrate supplementation on FMD by analyzing the pharmacokinetics of creatine nitrate supplementation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Health Services Research
- 盲法
- Double (Participant, Investigator)
入排标准
- 接受健康志愿者
- 是
入选标准
- •you are an apparently healthy and recreationally active male between the ages of 18 and 40;
排除标准
- •you have a history of treatment for metabolic disease (i.e., diabetes), hypertension, hypotension, thyroid disease, arrhythmia and/or cardiovascular disease;
- •you are currently using prescription medications;
- •you have a history of smoking;
- •you drink excessively (i.e., 12 drinks per week or more);
- •you have a recent history of creatine supplementation within six weeks of the start of supplementation;
结局指标
主要结局
Examine creatine vs. creatine nitrate supplementation by assessing body composition
时间窗: One day
Examine creatine vs. creatine nitrate supplementation by assessing serum creatine levels
时间窗: One day
Examine creatine vs. creatine nitrate supplementation by assessing serum nitrate levels
时间窗: One day
Examine creatine vs. creatine nitrate supplementation by assessing serum nitrite levels
时间窗: One day
Examine creatine vs. creatine nitrate supplementation by assessing flow-mediated dilation (FMD) via ultrasonography
时间窗: One day
Examine creatine vs. creatine nitrate supplementation by assessing body water
时间窗: One day
次要结局
- Measure standard clinical chemistry panels in the blood to evaluate safety(One day)
- Measure side effects to evaluate safety utilizing a side effects questionnaire(One day)
- Measure heart rate to evaluate safety(One day)
- Measure blood pressure to evaluate safety(One day)