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临床试验/NCT04938401
NCT04938401Unknown不适用

Construction and Application of a Risk Prediction Model Forepistaxis After Endoscopic Transsphenoidal Pituitary Tumor Resection

Wang Ying supervisor nurse0 个研究点目标入组 1 人开始时间: 2021年7月2日最近更新:
适应症

试验速览

阶段
不适用
发起方
入组人数
1
主要终点
Incidence of epistaxis

研究概览

简要总结

(1) Objective to establish an evaluation system for predicting the risk of epistaxis after endoscopic transsphenoidal pituitary surgery( 2) Objective to determine the risk factors of epistaxis after endoscopic transsphenoidal pituitary adenoma surgery. Referring to domestic and foreign literature, combined with experts' opinions, the related risk factors that may cause postoperative nosebleed of pituitary adenoma are: 22 patients and surgical factors. 3) Objective to establish a risk prediction model of epistaxis after endoscopic transsphenoidal pituitary tumor resection. According to the occurrence of epistaxis, the patients in the modeling group were divided into epistaxis group and non epistaxis group. The risk factors of epistaxis were taken as the independent variable, and the occurrence of epistaxis was taken as the dependent variable. The variables with statistical significance in univariate analysis were included in the multivariate logistic regression model, and the risk prediction model of epistaxis after pituitary tumor resection was established by back LR method.(4) Objective to verify the risk prediction model of endoscopic transsphenoidal pituitary adenoma epistaxis. The validation model is used to validate the prediction model, and the Hosmer-Lemeshow degree is used to match the model. The area under the receiver operating characteristic curve (ROC) was used to evaluate the validity of the model.(5) Application of risk prediction model.

研究设计

研究类型
Observational
观察模型
Case Only
时间视角
Cross Sectional

入排标准

年龄范围
14 Years 至 90 Years(Child, Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Those who met the diagnostic criteria of pituitary tumor and received transsphenoidal endoscopic surgery during hospitalization; Patients with informed consent; Age ≥ 14 years old.

排除标准

  • quitters; patients with incomplete clinical data;

结局指标

主要结局

Incidence of epistaxis

时间窗: up to 24 weeks

Overall incidence of epistaxis

次要结局

未报告次要终点

研究者

发起方
Wang Ying supervisor nurse
申办方类型
Other
责任方
Sponsor Investigator
主要研究者

Wang Ying supervisor nurse

Neurosurgery 5 Ward

Second Affiliated Hospital, School of Medicine, Zhejiang University

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