NCT04642690终止不适用
The Association Between Nitrates, Nitrosylated Proteins, and Interleukin-8 in Barrett's Esophagus and Esophageal Adenocarcinoma
适应症
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- Mayo Clinic
- 入组人数
- 9
- 试验地点
- 1
- 主要终点
- Serum and Tissue Biomarkers
研究概览
简要总结
The purpose of this study is to determine if nitrates and IL-8 (which are found in food and throughout the body regulating stomach acidity) play a role in Barrett's Esophagus and/or Esophageal Adenocarcinoma severity and if screening for these biomarkers can help predict patients that are more at risk for developing worsening disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients undergoing a clinicallly-indicated Esophagogastroduoedoscopy (EGD).
排除标准
- •Comorbid inflammatory medical condition.
- •Use of antiinflammatory (aspirin and NSAIDs) or immunosuppressants over the past 1 week.
- •Use of nitrate containing medication in the past 1 week.
- •Consumption of nitrate rich foods in preceding 24 hours.
- •Known allergy to meat or nitrates
结局指标
主要结局
Serum and Tissue Biomarkers
时间窗: Baseline
Levels of IL-8 in patients diagnosed BE dysplasia and EAC
Nitrate Levels
时间窗: Baseline
Nitrate levels in serum, saliva and tissue in patients with normal squamous epithelium, erosive esophagitis, non-dysplastic BE (NDBE), and BE with high-grade dysplasia (HGD) or EAC
次要结局
- Biomarkers and disease progression(Baseline)
研究者
Cadman Leggett
Principal Investigator
Mayo Clinic
研究点 (1)
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