Pilot Study Into the Structural Local Molecular Environment Following an ACL Injury
试验速览
- 阶段
- 不适用
- 入组人数
- 5
- 试验地点
- 1
- 主要终点
- Pattern of injury on High Definition MRI measured by comparison with 3t MRI images
研究概览
简要总结
The aim of this pilot study is to understand the biological changes that occur within the knee joint following injury to the anterior cruciate ligament (ACL). This will be achieved through aspiration and analysis of the haemarthrosis which fills the knee following injury. The study will look at inflammatory and healing responses using DNA, RNA and protein analysis.
This, combined with high resolution imaging of the knee and surrounding soft tissue structures, may enable a more patient specific approach to treatment of ACL injury.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of ACL injury confirmed by MRI
- •All participants must have the capacity to provide informed consent to participate
- •Participants must be able to comply with required study visit
排除标准
- •Participants outside of the specified age range
- •Participants who do not have the mental capacity to make informed decisions
- •Participants who have meniscal pathology or other injuries requiring urgent surgery
结局指标
主要结局
Pattern of injury on High Definition MRI measured by comparison with 3t MRI images
时间窗: Last visit, usually 28 days
Outcome will illustrate any additional benefit of high definition MRI
次要结局
- Identification of acute inflammatory mediators measured by NanoString molecular analysis(Last visit, usually 28 days)
研究者
Mr Stephen McDonnell
Principal Investigator
Cambridge University Hospitals NHS Foundation Trust