The Effect of Maximal Exercise on Matrix Metalloproteinase Enzyme and Its Inhibitor (MMP9 and TIMP1) and The Role of MMP9 -1562 C/T and TIMP1 372 T/C Polymorphisms
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 86
- 试验地点
- 2
- 主要终点
- MMP9 -1562 C/T, TIMP1 372 T/C polymorphisms
研究概览
简要总结
Matrix metalloproteinases (MMPs) play a critical role in the remodeling and regeneration of skeletal muscle. Studies which investigate exercise and effects of MMPs and tissue inhibitors of matrix metalloproteinases (TIMPs) are contradictory. Also the role of MMP9 -1562 C/T and TIMP1 372 T/C polymorphisms on exercise are unclear. In accordance with this conditions the hypothesis of the study are as follows:
- Levels of basal serum MMP9 and TIMP1 are different between athletes (volleyball, basketball, handball) and sedentary people.
- Levels of serum MMP9 and TIMP1 response to maximal exercise are different between athletes (volleyball, basketball, handball) and sedentary people .
- Relationship between levels of serum MMP9 and TIMP1 response to maximal exercise are different between athletes (volleyball, basketball, handball) and sedentary people.
- Levels of basal serum MMP9 and TIMP1 are related to MMP9 -1562 C/T and TIMP1 372 T/C polymorphisms.
- Relationship between levels of serum MMP9 and TIMP1 response to maximal exercise and MMP9 -1562 C/T and TIMP1 372 T/C polymorphisms are different between athletes (volleyball, basketball, handball) and sedentary people.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Group of athletes:
- •Male basketball players who have been training regularly for at least last 3 months.
- •Male volleyball players who have been training regularly for at least last 3 months.
- •Male handball players who have been training regularly for at least last 3 months.
- •Group of sedentary people:
- •Male individuals with similar physical characteristics to the group of athletes
- •Male individuals who have not exercise regularly for at least last 3 months.
- •Exclusion Criteria(For two groups):
- •Smoking regularly
- •Drinking alcohol regularly
- •Using drug and antioxidant substance
- •Being obese,
- •Being sick or having disability
排除标准
- 未提供
结局指标
主要结局
MMP9 -1562 C/T, TIMP1 372 T/C polymorphisms
时间窗: Yo-Yo Intermittent Recovery Test level 1 (the test performed until the subject is exhausted, the test lasts 10-20 minutes according to endurance capacity of the participants)
The role of MMP9 -1562 C/T and TIMP1 372 T/C polymorphisms on the effect of acute maximal exercise on serum MMP9 and TIMP1 in athletes and sedentary people.
Level of MMP9 and TIMP1
时间窗: Yo-Yo Intermittent Recovery Test level 1 (the test performed until the subject is exhausted, the test lasts 10-20 minutes according to endurance capacity of the participants)
The effect of acute maximal exercise on serum MMP9 and TIMP1 levels in athletes and sedentary people.
次要结局
- Level of indicators of muscle damage and inflammation and oxidative stress(Yo-Yo Intermittent Recovery Test level 1 (the test performed until the subject is exhausted, the test lasts 10-20 minutes according to endurance capacity of the participants))
- Level of blood lipids and lipoproteins, glucose, urea, creatinine, hemogram(Yo-Yo Intermittent Recovery Test level 1 (the test performed until the subject is exhausted, the test lasts 10-20 minutes according to endurance capacity of the participants))
研究者
Merve Koca Kosova
research assistant
Dokuz Eylul University