An evaluation of the effect of an angiotensin-converting enzyme (ACE) inhibitor on the growth rate of small abdominal aortic aneurysms - Evaluation of effect of ACE inhibitors on small aneurysm growth rate

Imperial College0 个研究点目标入组 225 人开始时间: 2010年11月15日最近更新: 2015年8月4日

适应症

试验速览

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•All men or women, aged 60 or greater years, with AAA <5.5 cm and with a systolic BP <150mmHg will be eligible for inclusion in the trial. For patients whose systolic BP is >150mmHg, treatment will be initiated with a diuretic Indapamide SR 1.5mgs by the principal investigator and/or amlodipine (5mg daily) initiated by the general Practitioner. If the SBP subsequently falls to <150mmHg on this medication subjects would then be eligible for inclusion into the study.
•Are the trial subjects under 18? no
•Number of subjects for this age range: 0
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 0
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range 0

•Patients already receiving an ACE-inhibitor or amlodipine 10mg daily or an angiotensin II receptor blocker drug (ARB) who cannot be converted to diuretic therapy and/or lower doses of amlodipine for treatment of their blood pressure. Patients with known renal artery stenosis (>50%). Patients with baseline serum creatinine >180 Those unable to give informed consent and those too frail to travel for 3-monthly surveillance.

发起方

Imperial College