Physician and Patient Preferences for Cell Therapies in Advanced Solid Tumors: A Discrete Choice Experiment
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 1,020
- 试验地点
- 1
- 主要终点
- Part-worth utility coefficients (preference weights) for cell therapy benefit-risk attributes
研究概览
简要总结
Cell therapies - including chimeric antigen receptor T-cell (CAR-T) therapy, tumor-infiltrating lymphocyte (TIL) therapy, T-cell receptor-engineered T-cell (TCR-T) therapy, and natural killer (NK) cell therapy - are emerging treatments for advanced solid tumors. However, their benefit-risk profiles remain uncertain: objective response rates in solid tumors are generally low, treatment-related toxicities such as cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) can be severe, and the manufacturing process is lengthy and costly. Little is known about how physicians and patients weigh these benefits, risks, and burdens when considering cell therapy for advanced solid tumors.
This cross-sectional, survey-based observational study will use a discrete choice experiment (DCE) to quantify and compare treatment preferences among approximately 420 oncology physicians and 600 patients with advanced solid tumors in China. Each participant will complete a one-time online questionnaire containing a series of hypothetical treatment choices. The study will estimate the relative importance of key treatment attributes (efficacy, safety, treatment burden, and cost), the maximum acceptable risk that participants are willing to tolerate in exchange for improved efficacy, and differences in preferences between physicians and patients. The findings will inform shared decision-making, cell therapy development, regulatory benefit-risk assessment, and health policy.
详细描述
This is a cross-sectional, questionnaire-based observational study using a discrete choice experiment (DCE) to elicit treatment preferences from oncology physicians and patients with advanced solid tumors. The study is designed and will be reported in accordance with the ISPOR good research practice guidelines for conjoint analysis. DCE attributes and levels will be developed through a structured process combining a literature review, expert consultation, and cognitive pretesting, and will span the efficacy, safety, treatment burden, and cost domains. A D-optimal fractional factorial design will be used to generate the choice tasks; each participant will be randomly assigned to a block of choice tasks, each presenting pairs of unlabeled hypothetical cell therapy profiles. Preference weights (part-worth utilities) will be estimated using random-parameters logit (mixed logit) models. Secondary analyses will examine the relative importance of attributes, maximum acceptable risk (MAR), marginal willingness to pay (mWTP) where applicable, differences in preferences between physicians and patients, and preference heterogeneity using latent class analysis and interaction-term models. Prespecified sensitivity analyses will be conducted to assess the robustness of the findings.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Physicians
- •Physicians must meet ALL of the following criteria:
- •Hold a valid medical practitioner license issued in the People's Republic of China and currently practice at a medical institution in China;
- •Specialize in medical oncology or another specialty directly involved in the diagnosis and treatment of solid tumors (e.g., thoracic oncology, gastrointestinal oncology, genitourinary oncology, or gynecologic oncology; surgical oncologists or radiation oncologists with prescribing authority for systemic anticancer therapy are also eligible);
- •Hold a professional title of attending physician or above;
- •Have directly participated in systemic treatment decision-making for patients with advanced (unresectable stage III or stage IV) solid tumors within the past 12 months;
- •Have a basic understanding of cell therapies (e.g., CAR-T, TIL, TCR-T, and NK cell therapies) and their therapeutic principles;
- •Participate voluntarily and provide electronic informed consent.
- •Patients must meet ALL of the following criteria:
- •Aged 18 years or older;
- •Histologically or cytologically confirmed advanced solid tumor (unresectable stage III or stage IV; e.g., non-small cell lung cancer, hepatocellular carcinoma, colorectal cancer, gastric cancer, melanoma, or ovarian cancer);
- •Received at least one prior line of systemic anticancer therapy (chemotherapy, targeted therapy, immune checkpoint inhibitors, or other cellular immunotherapy) in the advanced or metastatic setting;
- •Eastern Cooperative Oncology Group (ECOG) performance status of 0-2, with adequate cognitive and physical capacity to complete the questionnaire;
- •Able to understand the questionnaire content independently or with assistance from a study coordinator;
- •Participate voluntarily and provide electronic informed consent.
排除标准
- •Physicians
- •Physicians meeting ANY of the following criteria will be excluded:
- •Individuals engaged exclusively in basic research without direct involvement in clinical patient care;
- •Individuals unable, for any reason, to understand the questionnaire content or make independent judgments.
- •Patients meeting ANY of the following criteria will be excluded:
- •Patients who are unaware of their tumor stage or treatment status;
- •Severe cognitive impairment or psychiatric disorders that preclude comprehension of the questionnaire content or independent judgment;
- •Estimated life expectancy of less than 3 months as assessed by the treating physician, or insufficient physical capacity to complete the questionnaire;
- •Uncontrolled acute illness or other urgent medical conditions that make study participation inadvisable.
研究组 & 干预措施
Cohort 1: Physicians
Licensed oncology physicians who have participated in systemic treatment decision-making for patients with advanced solid tumors within the past 12 months (approximately 420 participants).
干预措施: Not applicable- observational study (Other)
Cohort 2: Patients
Adults with histologically or cytologically confirmed advanced solid tumors (unresectable stage III or stage IV) who have received at least one prior line of systemic anticancer therapy (approximately 600 participants).
干预措施: Not applicable- observational study (Other)
结局指标
主要结局
Part-worth utility coefficients (preference weights) for cell therapy benefit-risk attributes
时间窗: Day 1
Preference weights (part-worth utility coefficients) for all attribute levels will be estimated using a random-parameters logit (mixed logit) model, fitted separately in the physician and patient cohorts. Each coefficient represents the marginal change in utility associated with moving from the reference level to a given attribute level. The unit of measure is the preference weight, reported with 95% confidence intervals; within an attribute, a higher weight indicates a more preferred level.
次要结局
- Difference in preference weights for cell therapy benefit-risk attributes between patients and physicians(Day 1)
- Maximum acceptable risk (MAR) of treatment-related adverse events in exchange for improved efficacy(Day 1)
- Marginal willingness to pay (mWTP) for improvements in cell therapy attributes(Day 1)
研究者
Weijia Fang, MD
M.D.
Zhejiang University