Corelation Between Circulating Nuclearsome and SIRS Happened After Congential Cardiac Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- the perioperation change of histone level
研究概览
简要总结
In this study，the investigators want to determine the corelation between circulating nuclearsome and the development of SIRS occured after congenital cardiac surgery, including the serverity of organ damage and inflamation.
详细描述
Blood was collected from study participants at 6 time points; 1) post-anesthesia induction, 2) post-op hour 0, 3) post-op hour 4, 4) post-op hour 24, 5) post-op hour 48, and 6) post-op hour 72. At each of the 6 time points blood was analyzed for levels of the following:histone,blood routine test , c-reaction protein, procalcitonin, N-terminal pro-brain natriuretic,the hepatorenal function，cardiac function and pulmonary function
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 1 Month 至 3 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •children with congenial heart disease
排除标准
- •Less than 2.5kg
- •Prematurity less than 37 weeks estimated gestational age
- •Renal failure as described by the pediatric RIFLE criteria
结局指标
主要结局
the perioperation change of histone level
时间窗: preoperation to 72 hours after congential cardiac surgery
次要结局
- the perioperation change of blood routine test(preoperation to 72 hours after congential cardiac surgery)
- the perioperation change of cardiac function(preoperation to 72 hours after congential cardiac surgery)
- the perioperation change of c-reaction protein level(preoperation to 72 hours after congential cardiac surgery)