Imaging Markers of High-Risk Plaque Phenotype for Predicting Post-PCI Outcomes (IMPACT-PCI) Study: A Multicenter Cohort Study Based on Coronary CT Angiography
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 2,000
- 试验地点
- 3
- 主要终点
- Major adverse cardiovascular events (MACE)
研究概览
简要总结
Despite the widespread use of stents, previous studies have shown that stent implantation mainly relieves symptoms but may not significantly improve long-term outcomes in patients with stable coronary artery disease. Identifying the types of plaques that are most likely to benefit from stenting is essential for improving personalized treatment. This study explores whether coronary computed tomography angiography (CCTA)-derived imaging biomarkers of coronary plaques are associated with increased risk of adverse outcomes after percutaneous coronary intervention (PCI). Around 2,000 patients who underwent CCTA followed by stent placement were included. Advanced software was used to quantify plaque inflammation and composition. Findings from this research may help guide personalized treatment strategies in patients undergoing PCI.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients aged 18 years or older;
- •patients who underwent clinically indicated PCI within 30 days following CCTA;
- •CCTA demonstrating the presence of coronary atherosclerotic plaque.
排除标准
- •patients whose PCI within 30 days after CCTA was performed on an emergency basis;
- •elevated cardiac troponin levels within the 3 months preceding PCI;
- •inadequate CCTA image quality;
- •balloon-only or mixed stent/balloon PCI strategies;
- •PCI for non-atherosclerotic lesions (e.g., in-stent restenosis, spontaneous coronary dissection);
- •history of coronary artery bypass grafting;
- •heart failure;
- •non-ischemic cardiomyopathy;
- •significant valvular heart disease;
- •refractory hypertension;
- •persistent atrial fibrillation.
结局指标
主要结局
Major adverse cardiovascular events (MACE)
时间窗: From the date of PCI until December 2024 (minimum 2-year follow-up)
Composite of cardiovascular death, non-fatal myocardial infarction, repeat revascularization, and hospitalization for unstable angina.
次要结局
未报告次要终点
研究者
Bin Lu
Principal Investigator
Chinese Academy of Medical Sciences, Fuwai Hospital