A Phase II Study of Dasatinib (NSC 732517) in Previously-Treated Patients With Metastatic Colorectal Cancer
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 19
- 试验地点
- 1
- 主要终点
- Progression-free Survival Rate
研究概览
简要总结
This phase II trial is studying dasatinib to see how well it works in treating patients with previously treated metastatic colorectal cancer. Dasatinib may stop the growth of tumor cells by blocking some of the enzymes needed for their growth.
详细描述
PRIMARY OBJECTIVES:
I. Determine the progression-free survival of patients with metastatic colorectal cancer who have progressed on or following two prior chemotherapy regimens and are then treated with dasatinib.
SECONDARY OBJECTIVES:
I. Determine the objective response rates in patients treated with dasatinib. II. Determine the overall survival of patients treated with dasatinib. III. Determine the toxicity in patients treated with dasatinib.
TERTIARY OBJECTIVES:
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Histologically or cytologically confirmed colorectal cancer
- •Metastatic disease
- •Not curable by surgical resection
- •Archival tumor tissue available
- •Measurable disease, defined as at least one unidimensionally measurable lesion ≥ 20 mm by conventional techniques or ≥ 10 mm by spiral CT scan
- •Measurable disease must be outside of a prior radiation port
- •Documented disease progression either during or after prior chemotherapy treatment
- •No more than 2 prior chemotherapy regimens in the adjuvant or metastatic setting
- •Prior chemotherapy regimens must have contained a fluoropyrimidine (e.g., fluorouracil or capecitabine), oxaliplatin, and irinotecan
- •Patients who received no prior adjuvant therapy must have received 2 prior chemotherapy regimens for metastatic disease (e.g., FOLFOX followed by FOLFIRI)
- •Patients who received prior adjuvant therapy with a fluoropyrimidine plus oxaliplatin must have received no more than 1 chemotherapy regimen for metastatic disease that must have contained irinotecan
- •VEGF or EGFR inhibitors with prior chemotherapy allowed
- •No known brain metastases
- •Life expectancy > 3 months
- •ECOG performance status (PS) 0-2 or Karnofsky PS ≥ 60%
- •WBC ≥ 3,000/mm³
- •ANC ≥ 1,500/mm³
- •Platelet count ≥ 100,000/mm³
- •Total bilirubin ≤ 1.5 times upper limit of normal (ULN)
- •AST/ALT ≤ 2.5 times ULN (5 times ULN with liver metastases)
- •Creatinine normal or creatinine clearance ≥ 60 mL/min
- •Not pregnant or nursing
- •Negative pregnancy test
- •Fertile patients must use effective contraception
- •No history of allergic reactions attributed to compounds of similar chemical or biological composition to dasatinib
- •No QTc prolongation, defined as a QTc interval ≥ 480 msecs (Bazett correction)
- •No condition (e.g., gastrointestinal tract disease resulting in an inability to take oral medication or a requirement for IV alimentation, or active peptic ulcer disease) that would impair ability to swallow and retain dasatinib tablets
- •Prior partial colectomy is not considered an exclusion factor
- •No clinically significant cardiovascular disease including any of the following:
- •Myocardial infarction or ventricular tachyarrhythmia within the past 6 months
- •New York Heart Association class II -IV congestive heart failure
- •Major conduction abnormality (unless a cardiac pacemaker is present)
- •No uncontrolled intercurrent illness including, but not limited to, any of the following:
- •Ongoing or active infection
- •History of significant bleeding disorder (including congenital [e.g., von Willebrand's disease] or acquired [e.g., anti-factor VIII antibodies] disorders)
- •Large pleural effusions
- •Psychiatric illness or social situations that would limit compliance with study requirements
- •No currently active second malignancy other than non-melanoma skin cancer or carcinoma in situ of the cervix
- •Patients are not considered to have a currently active malignancy if they have completed therapy and have no evidence of recurrence for at least 5 years
- •At least 4 weeks since prior chemotherapy (6 weeks for nitrosoureas or mitomycin C) and recovered
- •At least 4 weeks since prior radiation therapy and recovered
- •No prior surgical procedures affecting absorption
- •No prior treatment with inhibitors of src, PDGFR, KIT, or EPHA2
- •More than 1 week since prior and no concurrent medications or substances that are potent inhibitors or inducers of CYP3A4
- •More than 1 week since prior and no concurrent medications that inhibit platelet function (e.g., aspirin, dipyridamole, epoprostenol, eptifibatide, clopidogrel, cilostazol, abciximab, ticlopidine, or any non-steroidal anti-inflammatory drug)
- •More than 1 week since prior and no concurrent agents that are generally accepted to have a risk of causing Torsades de Pointes, including quinidine, procainamide, disopyramide, amiodarone, sotalol, ibutilide, dofetilide, erythromycins, clarithromycin, chlorpromazine, haloperidol, mesoridazine, thioridazine, pimozide, cisapride, bepridil, droperidol, methadone, arsenic, chloroquine, domperidone, halofantrine, levomethadyl, pentamidine, sparfloxacin, or lidoflazine
- •No concurrent anticoagulants (e.g., warfarin, heparin/low molecular weight heparin [e.g., danaparoid, dalteparin, tinzaparin, or enoxaparin])
- •No concurrent combination antiretroviral therapy for HIV-positive patients
- •No concurrent grapefruit or grapefruit juice
- •No other concurrent investigational agents or commercial agents or therapies
排除标准
- 未提供
研究组 & 干预措施
Treatment (tyrosine Kinase Inhibitor)
Patients receive oral dasatinib twice daily on days 1-28. Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity.
干预措施: dasatinib (Drug)
Treatment (tyrosine Kinase Inhibitor)
Patients receive oral dasatinib twice daily on days 1-28. Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity.
干预措施: laboratory biomarker analysis (Other)
结局指标
主要结局
Progression-free Survival Rate
时间窗: From the start of treatment to the time of disease progression or death from any cause, assessed at 4 months after completion of treatment (i.e., up to 12 months.)
Progression will be evaluated in this study using the new international criteria proposed by the Response Evaluation Criteria in Solid Tumors (RECIST) Committee. Patients who are still alive and have not progressed will be censored at the date of the last negative examination. A Simon (1989), optimal, two-stage design will be employed. The progression-free survival count will be the proportion of subjects who are alive and progression-free at 4 months.
次要结局
- Response Rate (RR) (Complete or Partial Responders)(Every 2 courses, assessed up to 8 weeks after completion of study treatment (i.e., up to 10 months))
- Incidence of Somatic Mutations(1 year)
- Association Between the Incidence of Total C-src and Phosphorylated C-src Expression and Response(4 months)
- Change in Plasma Vascular Endothelial Growth Factor (VEGF) Levels Over 15 Days(At baseline and day 15)