Beta-blockade Reduces Catabolism in Severely Injured Trauma Patients
试验速览
- 阶段
- 2 期
- 状态
- 终止
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- Change in REE vs. Controls
研究概览
简要总结
Critically injured patients endure a period of hypermetabolism/catabolism after being resuscitated. The metabolic cost of this may be measured in loss of lean body mass, poor wound healing, susceptibility to infection and long hospital stays. While there have been some data to suggest that hypermetabolism can be ameliorated in burn patients by beta blockade, to our knowledge, a prospective trial in trauma patients has not yet been done. Our hypothesis is that nonselective beta blockade will reduce catabolism, improve glucose control, blunt loss of lean body mass, decrease infections and improve outcome in a cohort of critically injured patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ISS>25, stable at 48 hours after injury
- •Fully resuscitated
- •Ventilated
- •Exclusion Criteria Include:
- •Intracranial hypertension requiring active treatment
- •Hypotension/Pressors
- •Already on beta blocker for a standard indication
排除标准
- 未提供
研究组 & 干预措施
Propranol Treatment
干预措施: Propranolol (Drug)
结局指标
主要结局
Change in REE vs. Controls
时间窗: ICU admission date to ICU discharge or death
次要结局
- Changes in Protein Metabolism Measurements(ICU admission date to ICU discharge or death)
- Alterations in Neuroendocrine and Immunoinflammatory Measurements(ICU admission date to ICU discharge or death)
- Clinical Outcome Measurements(ICU admission date to ICU discharge or death)