Vaporized Nicotine and Autonomic Control
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 入组人数
- 16
- 试验地点
- 2
- 主要终点
- Blood pressure (measured from the finger)
研究概览
简要总结
E-cigarettes are marketed as an alternative to smoking for those who want to decrease the health risks of tobacco. Tobacco cigarettes increase heart rate (HR) and arterial pressure, while reducing muscle sympathetic nerve activity (MSNA) through sympathetic baroreflex inhibition. The acute effects of e-cigarettes on arterial pressure and MSNA have not been reported: our purpose was to clarify this issue. Using a randomized crossover design, participants inhaled on a JUUL containing nicotine (59 mg/ml) and a similar placebo e-cigarette (0 mg/ml).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
盲法说明
Participants were not informed if they were to receive nicotine or placebo
入排标准
- 年龄范围
- 21 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- •Individuals with a history of hyperthyroidism
- •Women currently taking oral contraceptives, are pregnant or breast-feeding, or trying to become pregnant
- •Individuals currently taking prescription drugs.
- •Individuals with respiratory illnesses (e.g., asthma, chronic obstructive pulmonary disease, reactive airway disease, etc.)
- •Individuals with hypertension (systolic >130 and/or diastolic > 80).
- •Individuals with a history of tobacco or vaporized nicotine use.
- •Individuals who have been diagnosed with diabetes
- •Individuals who are under the age of 18 or over the age of 40
结局指标
主要结局
Blood pressure (measured from the finger)
时间窗: Experiments were separated by one month. Beat-to-beat arterial pressure was recorded for ten minutes at rest, during ten minutes of e-cigarette use, and for ten minutes during recovery. The last 5 minutes of each section were averaged.
Effects of electronic cigarettes on both systolic and diastolic arterial pressure.
Muscle sympathetic nerve activity (measured with the microneurography technique)
时间窗: Experiments were separated by one month. MSNA was recorded for ten minutes at rest, during ten minutes of e-cigarette use, and for ten minutes during recovery. The last 5 minutes of each section were averaged.
Effects of electronic cigarettes on muscle sympathetic nerve activity (MSNA)
次要结局
未报告次要终点