inking protein profiles to disease progression and clinical expression in Parkinson*s disease - Protein expression in Parkinson's disease

Vrije Universiteit Medisch Centrum0 个研究点目标入组 282 人开始时间: 待定最近更新: 2024年5月6日

适应症

试验速览

暂无简介。

•(1) Patients of the outpatient clinic for movement disorders with a suspected parkinsonian syndrome, based upon the presence of at least one of the following parkinsonian symptoms: hypokinesia, bradykinesia, rigidity, tremor or postural instability.
•(2) Patients already under treatment at the outpatient clinic for movement disorders and diagnosed with PD or one of the following other parkinsonian syndromes: MSA, PSP, vascular parkinsonism.
•(3) Being able to understand the aim of the study and the study procedure and give written informed consent;HEALTHY CONTROLS
•Being able to understand the aim of the study and the study procedure and give written informed consent

•(1) A history of neurological disorders other than a parkinsonian syndrome, that affect the central nervous system or are known to influence CSF proteins
•(2) Use of anticoagulants or indications for coagulation disorders
•(3) Infected skin over the needle entry side for lumbar puncture
•(4) Signs of raised intracranial pressure
•(5) Unwillingness to be informed of unexpected medical findings;HEALTHY CONTROLS
•(1) A history of neurological disorders that affect the central nervous system or are known to influence CSF proteins
•(2) Abnormal findings at general neurological examination
•(3) Use of anticoagulants or indications for coagulation disorders
•(4) Infected skin over the needle entry side for lumbar puncture
•(5) Signs of raised intracranial pressure
•(6) Unwillingness to be informed of unexpected medical findings

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