PICR-b Nasopharyngeal S. Pneumoniae and Nasal S. Aureus Carriage Study
试验速览
- 阶段
- 不适用
- 入组人数
- 12,800
- 试验地点
- 1
- 主要终点
- S. pneumoniae carriage
研究概览
简要总结
Objective: PCV effects on S. pneumoniae and S. aureus carriage in a population based study. The major specific aims:
- To compare different PCV vaccination policies, by cross-sectional repeated surveillance of closely related populations living in regions with different vaccination policies.
- To compare the epidemiology, predictors and outcomes of antibiotic resistant S. aureus and S. pneumoniae in different regions of the PICR.
Study design: Annual / Biannual cross-sectional surveillance of nasal S. aureus carriage and nasopharyngeal S. pneumoniae carriage in children and one of their parents.
详细描述
Study design: Annual / Biannual cross-sectional surveillance of nasal S. aureus carriage and nasopharyngeal S. pneumoniae carriage in children and one of their parents.
PICR districts: 1. Palestinian Authority (PA) - particularly: Bethlehem, Ramallah and Nabulus. 2. East Jerusalem (EJ) 3. Central Israel (IL) - particularly: Rishon Lezion, Bat Yam, Holon 4. Gaza strip (GZ) - 12 regions including cities/villages in central/northern Gaza.
Study population:
Child (age 0-5y) & Parent who attend clinics (for any reason).
Exclusion criteria:
研究设计
- 研究类型
- Observational
- 观察模型
- Ecologic Or Community
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- — 至 5 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Any child younger than 5 years, visiting the participating clinics during the surveillance period
排除标准
- •Older than 5 years
- •Previously participated in the study.
- •Sibling has participated in the study.
- •Parent does not agree to sign informed consent
结局指标
主要结局
S. pneumoniae carriage
时间窗: 1 Day
S. pneumoniae carriage of children and parents by the different groups
次要结局
- S. aureus carriage(1 Day)
- Carriage of antibiotic resistant S. pneumonia(1 Day)
- Carriage of MRSA(1 Day)
- Carriage of Vaccine-type S. pneumoniae(1 Day)
- Carriage of piliated S. pneumonia(1 Day)
研究者
Gili Regev-Yochay MD
Head of Infect Dis Epi Section, Gertner
Sheba Medical Center