Evaluating the Impact of Early Versus Delayed 5 Alpha Reductase Inhibitor Treatment on the Risk of Emergent Surgery in Men With Benign Prostatic Hyperplasia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 4,068
- 主要终点
- Number of Participants Who Experienced Progression of Disease
研究概览
简要总结
This retrospective study aims to assess the impact of early vs delayed 5-alpha-reductase inhibitor (5ARI) therapy in patients with BPH on alpha-blocker (AB) therapy and the risk of acute urinary retention (AUR), prostate-related surgery, and emergency surgery (defined as prostate surgery occurring within 30 days of AUR). The MarketScan database will be utilized for this study (2000-2008).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 50 Years 至 —（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •aged 50 years or older
- •diagnostic claim for BPH
- •prescription claim for an AB and a 5ARI in the observation period (5ARI must occur within a 6-month window after the AB).
- •continuously eligible for 6 months prior to and 12 months after index prescription date
排除标准
- •prostate or bladder cancer during the study period
- •any prostate-related surgical procedure within 5 months of the index prescription date
- •prescription claim for finasteride 1 mg for male pattern baldness during the study period
- •5ARI therapy prior to initiation of AB therapy
研究组 & 干预措施
Early initiation of 5ARI therapy
Patients starting 5ARI therapy within 30 days of initiating AB therapy
干预措施: 5ARI + AB (Drug)
Delayed initiation of 5ARI therapy
Patients starting 5ARI therapy more than 30 days but less than 6 months from the initiation of AB therapy
干预措施: 5ARI + AB (Drug)
结局指标
主要结局
Number of Participants Who Experienced Progression of Disease
时间窗: Up to 5 months
The number of participants in each study group with a treatment code for acute urinary retention, surgery, or emergency surgery (defined as surgery within 30 days following a diagnosis of acute urinary retention) was measured.
次要结局
- Number of Participants With the Indicated Time Between Acute Urinary Retention and Subsequent Surgery(6 months)