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临床试验/NCT02457936
NCT02457936已完成不适用

Examining Cognitive Mechanisms of Clinical Improvement Following Mindfulness Based Cognitive Therapy for Depressed Individuals

Massachusetts General Hospital2 个研究点 分布在 1 个国家目标入组 52 人开始时间: 2015年4月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
52
试验地点
2
主要终点
Change from baseline in depressive symptoms as measured by the Hamilton Depression Rating Scale

研究概览

简要总结

Depression one of the leading causes of disability worldwide. Individuals suffering from depression typically exhibit impairments in various mental abilities, such as the ability to effectively direct and control attention and the ability to switch between thinking about different things and concepts (commonly referred to as "cognitive flexibility").

Mindfulness meditation training is a technique which involves focusing one's awareness on the present moment, while calmly acknowledging and accepting one's feelings, thoughts, and bodily sensations. It has been well documented to improve depressive symptoms and prevent recurrence of depressive episodes, yet little is known about how mindfulness does so and what are the underlying mental mechanisms involved. Here the investigators propose to examine the efficacy of an 8-week mindfulness training program in improving the ability to direct and control attention, as well as in cognitive flexibility.

Individuals diagnosed with recurrent depression will undergo an 8-week mindfulness training program. Participants' depressive symptoms as well as their performance on measures of attention and cognitive flexibility will be examined. Participants will be assigned to mindfulness training or a wait-list control group. Half of the participants will be examined before and after the mindfulness training program and the other half will be tested 8-weeks apart and then begin their training.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
None

入排标准

年龄范围
18 Years 至 65 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Reporting dysphoria for at least two months prior
  • HAM-D score of at least 11
  • No history of psychiatric disorders of psychotic features, neurological disorders, or substance abuse in the past 6 months
  • Verified age between 18-65 years old
  • Had no suicidal attempts during the past six months
  • No prior experience with MBCT or other systematic meditation programs

排除标准

  • History of psychosis, neurological disorder, and substance abuse for the past 6 months
  • Suicide attempt in past 6 months
  • Prior experience with MBCT or other systematic meditation program

结局指标

主要结局

Change from baseline in depressive symptoms as measured by the Hamilton Depression Rating Scale

时间窗: Once upon recruitment (baseline), and a second time at 8-10 weeks following the MBCT program

Change from baseline in attention regulation, as measured by the Attention Network Test

时间窗: Once upon recruitment (baseline), and a second time at 8-10 weeks following the MBCT program

Change from baseline in cognitive flexibility, as measured by a computer task involving task-switching and by the Torrance Test for Creative Thinking

时间窗: Once upon recruitment (baseline), and a second time at 8-10 weeks following the MBCT program

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Jonathan Greenberg

Postdoctoral research fellow

Massachusetts General Hospital

研究点 (2)

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