NCT03393676Unknown不适用
Preoperative Chronic Pain Increases the Risk of Early Postoperative Cognitive Dysfunction in Elderly Patients Undergoing Hip Joint Replacement Surgery: a Prospective Observational Cohort Study
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- POCD incidence 7 days (or before leaving hospital) after surgery
研究概览
简要总结
The purpose of this study is to investigate whether preoperative pain is the risk factor of POCD in elder patients.
详细描述
Postoperative cognitive dysfunction (POCD) occurs mainly in aged patients. The mechanism of POCD is not clear yet and no effective therapy method. In the present study, we conducted a single-center observational prospective cohort trial in elder patients who undergoing hip joint replacement surgery with general anesthesia to test our hypothesis that preoperative chronic pain is one of the risk factors of POCD after major joint replacement surgery.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Elder than 65 years old
- •Speak Chinese Mandarin
- •Those who will undergo major low limb surgery like hemiarthroplasty or total hip arthroplasty with general anesthesia.
- •Signed the inform consent
- •American Society of Anesthesiologists classification I to II
排除标准
- •Existing cerebral disease, or have a history of neurological and psychiatric disease including Alzheimer Disease, stroke, epilepsy and psychosis
- •Existing cognitive impairment as evidenced by Mini-Mental State Examination scores below 24
- •Severe hearing or visual impairment
- •Unwillingness to comply with the protocol or procedures
- •Cannot communicate with Chinese Mandarin
- •Serious pulmonary, heart , liver or renal insufficiency patients
- •Had anesthesia or surgery within the past 30 days
结局指标
主要结局
POCD incidence 7 days (or before leaving hospital) after surgery
时间窗: 7 days (or before leaving hospital)
POCD incidence 7 days (or before leaving hospital) after surgery
次要结局
- POCD incidence 2 months after surgery(2 months after surgery)
研究者
研究点 (2)
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