Young Smokers Have Impaired Airway Defense That is Not Associated With Pulmonary Function
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 72
- 试验地点
- 1
- 主要终点
- Exhaled Breath Condensate pH
研究概览
简要总结
Background: Smoking is a key factor for development and progression of chronic obstructive pulmonary disease (COPD). Although persons with COPD often have concomitant nasal disease, there are few studies that report physiological or inflammatory changes in the upper airways in young asymptomatic smokers. The investigators investigated physiologic and inflammatory changes in the nasal and lower airways of young smokers and if these changes were related to smoking history.
Methods: Seventy-two subjects aged ≤ 35 years (32 healthy nonsmokers and 40 young smokers) participated in this study. The investigators measured nasal mucociliary clearance (MCC), nasal mucus physical properties, cell count, myeloperoxidase and cytokines concentrations in nasal lavage fluid, exhaled breath condensate (EBC) pH and lung function.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy nonsmokers
- •asymptomatic smokers
- •after obtaining written informed consent
排除标准
- •inability to understand and follow commands
- •previous nasal surgery
- •respiratory infection in the previous 30 days
- •reported or diagnosed asthma
结局指标
主要结局
Exhaled Breath Condensate pH
时间窗: six months
次要结局
- mucociliary clearance by saccharine transit time test(six months)
研究者
Naomi Kondo Nakagawa
PT, MSc, PhD
University of Sao Paulo