Affective and Inflammatory Reactivity to Pain in Opioid Use Disorder
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 83
- 试验地点
- 1
- 主要终点
- Craving
研究概览
简要总结
The goal of this study is to investigate the association between response to pain and opioid craving in people with opioid use disorder. In this study, adults with opioid use disorder will be randomized to one of two brief education sessions followed by an assessment of response to pain. Investigators will test the association between response to pain and opioid craving.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Single (Investigator)
盲法说明
The investigator and data analyst will be blind to study condition.
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age 18 years or older;
- •diagnosis of opioid use disorder
- •chronic pain
- •ability to read and provide informed consent
排除标准
- •major psychiatric or medical condition that would interfere with participation
- •current opioid withdrawal
- •currently receiving opioid analgesic medication for pain
- •recent history of myocardial infarction or other serious cardiovascular condition
- •current peripheral neuropathy, active vasculitis or severe peripheral vascular disease
- •systematic inflammatory or autoimmune disorder
- •admitted to current treatment episode on an involuntary status
研究组 & 干预措施
Pain De-Catastrophizing
Brief behavioral education on how to modify the interpretation of pain.
干预措施: Pain De-Catastrophizing (Behavioral)
Pain Education
Brief behavioral education on pain.
干预措施: Pain Education (Behavioral)
结局指标
主要结局
Craving
时间窗: immediately after the intervention
Investigators will assess opioid craving using the Opioid Craving Scale, a participant-reported measure of opioid craving. This is a continuous measure that is quantified as a total scale score representing an average of the 3 items, with a range from 0-10, with higher scores reflecting more craving. This outcome is the mean score at a single time point, immediately following completion of the intervention.
次要结局
未报告次要终点
研究者
McHugh, R. Kathryn
Assistant Professor
Mclean Hospital