Severe Acute Respiratory Infections Surveillance in Belgium (2011-2020, Prior to COVID-19 Pandemic)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- Sciensano
- 入组人数
- 12,145
- 主要终点
- Number of participants positive for influenza viruses
研究概览
简要总结
The Belgian Severe Acute Respiratory Infections network (BELSARI-net) was implemented during the influenza season 2011-2012 following the recommendations of the World Health Organization (WHO) to monitor severity of influenza viruses in hospitals. The network is composed of 6 hospitals throughout the country, two in each administrative region (Flanders, Wallonia and Brussels-Capital), and operates during the influenza epidemic period (from the last week of December or first/second week of January to the third/last week of April, depending on when influenza virus circulation is detected by the general population, based on the Influenza-like illness (ILI) network of general practitioners).
Enrollment is performed for all cases matching the SARI case definition (based on WHO's case definition) and accepting to take part. A respiratory specimen is sampled systematically from each participant, and detailed clinico-epidemiological data, such as information on age, sex, symptoms and potential risk factors such as pregnancy or comorbidities (chronic respiratory diseases, asthma, chronic cardiovascular diseases, renal insufficiency, obesity, diabetes, hepatic or renal insufficiency, immunodeficiency, neuromuscular disease, pregnancy) is also collected. Participants are followed up during hospitalization for the occurrence of complications (detection of pneumonia based on chest radiography, development of acute respiratory distress syndrome (ARDS), requirement for respiratory assistance and/or for extracorporeal membrane oxygenation (ECMO), admission in intensive care unit (ICU)), or death (all-cause death).
The current project includes all the samples received by the Belgian National Influenza Centre (NIC) during the influenza seasons 2011-2012 till 2019-2020.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All pediatric and adult patients admitted to one of the 6 sentinel hospitals during the active surveillance and fulfilling the case definition of acute respiratory infection with onset within the last ten days, with history of fever or measured fever of ≥38°C, with cough and/or dyspnea, and overnight hospitalization.
排除标准
- •nosocomial infection, i.e. symptoms appearing after admission
结局指标
主要结局
Number of participants positive for influenza viruses
时间窗: within 10 days after symptom onset
result of influenza PCR detection test (typing and subtyping)
Number of participants positive for non-influenza viruses
时间窗: within 10 days after symptom onset (only routinely tested since influenza season 2015-2016)
results of non-influenza multiplex PCR detection test (16 targets)
Number of participants who died during hospitalization
时间窗: from date of hospital admission until date of death during hospitalization or date of hospital exit
alive or dead
次要结局
- Number of participants with at least one known risk factor(on date of hospital admission)
- Number of participants who experienced at least one complication(from date of hospital admission until date of death during hospitalization or date of hospital exit)