Effects of Inspiratory Muscle Training in Allogeneic Hematopoietic Stem Cell Transplantation Recipients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 主要终点
- Inspiratory and expiratory muscle strength (MIP, MEP)
研究概览
简要总结
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) causes various toxic effects in many body tissues, organs and systems such as immune, cardiovascular, pulmonary, gastrointestinal, neuroendocrine and musculoskeletal systems, liver, kidneys and skin.Available limited numbers of studies showed that inspiratory muscle weakness in allo-HSCT candidates and recipients. Although meta-analysis, systematic reviews and studies demonstrated beneficial effects of inspiratory muscle training on several outcomes in different disease groups; chronic obstructive pulmonary disease, bronchiectasis and heart failure, no published paper reported the effects of IMT in allo-HSC recipients.
详细描述
Thirty-eight allo-HSCT recipients (˃100 days past post-transplant status) were included. Before and after 6-week IMT, maximal and submaximal exercise capacity, respiratory and peripheral muscle strength, pulmonary functions, dyspnea and fatigue perception, depression and quality of life were evaluated. Primary outcome measurement was respiratory muscle strength, secondary outcomes were exercise capacity, dyspnea, peripheral muscle strength, quality of life, fatigue and depression.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Allo-HSC recipients (˃100 days past post-transplant status),
- •18-65 years of age,
- •Under standard medications
排除标准
- •Having cognitive disorder, orthopedic problem or neurological disease that were affecting functional capacity,
- •Additional heart and lung diseases such as asthma, chronic obstructive pulmonary disease, acute infections or pneumonia,
- •Problems prevented performing assessment and training such as visual problems and mucositis
结局指标
主要结局
Inspiratory and expiratory muscle strength (MIP, MEP)
时间窗: 6 weeks
Mouth pressure device
次要结局
- Peripheral muscle strength(6 weeks)
- Depression(6 weeks)
- Submaximal exercise capacity(6 weeks)
- Pulmonary function(6 weeks)
- Maximal exercise capacity(6 weeks)
- Fatigue(6 weeks)
- Dyspnea(6 weeks)
- Quality of life(6 weeks)
研究者
Meral Boşnak Güçlü
Assoc. Prof.
Gazi University