Effect of Pranayama on Peroxisome Proliferator-activated Receptor Gamma, Nuclear Factor Kappa B and Red Complex Microorganisms in Patients With Chronic Periodontitis
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 主要终点
- Clinical efficacy of pranayama in chronic periodontitis patients from baseline to 3 months
研究概览
简要总结
The objective of the study was to evaluate the levels of Peroxisome proliferator-activated receptor gamma (PPAR-γ), Nuclear factor-kappa B (NF-kB) and the presence of red complex microorganisms (RCM) such as Treponema denticola (T.d), Porphyromonas gingivalis (P.g) and Tannerella forsythia (T.f) in the subgingival tissues of chronic periodontitis subjects before and after intervention with pranayama as an adjunct to scaling and root planing.
详细描述
Sixty chronic periodontitis subjects were selected out of which 30 subjects (control group) were treated with scaling and root planing (SRP) and 30 subjects (pranayama group) also underwent SRP and pranayama for 3 months. Clinical parameters were recorded and the presence of PPAR-γ, NF-kB and RCM were assessed at baseline and after 3 months
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 30 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •presence of at least 20 teeth
- •Probing pocket depth ≥ 5 mm
排除标准
- •aggressive periodontitis
- •systemic disorders
- •pregnant & lactating females
- •smokers & alcoholics
- •immunocompromised individuals
结局指标
主要结局
Clinical efficacy of pranayama in chronic periodontitis patients from baseline to 3 months
时间窗: 3 months
Clinical attachment level is measured using Williams periodontal probe in millimeters with the criteria of 1 to 2 mm for slight periodontitis, 3 to 4 mm for moderate periodontits and greater or equal to 5 mm for severe periodontitis.
次要结局
- Efficacy of pranayama on perosxisome proliferator-activated receptor (PPAR)-γ in chronic periodontitis patients(3 months)
- Microbiological efficacy of pranayama in chronic periodontitis patients from baseline to 3 months(3 months)
- Efficacy of pranayama on nuclear factor-kappa B (NF-kB) in chronic periodontitis patients(3 months)
研究者
Dr.Jaideep Mahendra
Professor
Meenakshi Ammal Dental College and Hospital