Does Venous pCO2 Increase by 20 mmHg or More During Apnea Challenge Test?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 7
- 试验地点
- 2
- 主要终点
- Change in venous blood CO2 during apnea challenge test
研究概览
简要总结
One required examination for declaration of death by neurological criteria is the apnea challenge test. The apnea challenge test evaluates the medulla brainstem respiratory center response to a rise in CO2. The current guideline requires arterial sampling of CO2 and therefore either arterial puncture or arterial catheter placement for the examination. Arterial catheter is an invasive monitoring device and is not without complications. Recent studies have demonstrated that there is a direct correlation between peripheral venous and arterial blood gas measures and that peripheral venous CO2 measures may be used as alternatives to arterial CO2 measure.The purpose of this study is to evaluate brainstem response during the apnea challenge test to a rise in venous CO2 and correlate it with the rise in arterial measured CO2. The objective of this study is to demonstrate a similar rise between the venous and arterial CO2 during the apnea challenge test and eliminate the necessity of arterial blood sampling for the sole purpose of apnea challenge test in the future.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 1 Week 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age > 37 weeks gestation up to any adult age
- •Patients admitted to Pediatric Intensive Care unit (PICU), Neonatal Intensive Care Unit (NICU), Medical Intensive Care Unit (MICU) and Cardiothoracic Intensive Care Unit (CTICU)
- •Patients with irreversible brain injury where the attending physician will be performing death by neurological criteria examination as per hospital policy
- •Presence of arterial catheter or arterial blood sampling during apnea challenge test
- •Presence of central venous catheter or easily drawing peripheral intravenous catheter
排除标准
- •Age less or equal to 37 weeks gestation
- •Inability to perform apnea challenge test as determined by primary physician
- •Family request for Donation after Cardiac Death (DCD) or withdrawal of Life Sustaining Therapy
- •Bicarbonate infusion within 30 minutes of apnea challenge test
结局指标
主要结局
Change in venous blood CO2 during apnea challenge test
时间窗: During apnea challenge test
次要结局
- Change in End Tidal CO2 during apnea challenge test(During apnea challenge test)
研究者
Alireza Fathi, MD
Director of Critical Care Transport, Assoicate Medical Director, PICU
MemorialCare Health System