Pilot Study of 18F-FLT Pet Imaging in Cancer Patients
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- To test whether the cellular response to fractionated radiotherapy leads to observable global change in the uptake of 18F-FLT as assessed by PET imaging
研究概览
简要总结
Fractionated radiotherapy induces an observable change in the proliferative activity as assessed by pre-treatment and early-treatment 18F-FLT PET imaging. This study is designed to investigate 18F-FLT as a PET imaging agent for predicting treatment effectiveness in several tumors and will serve as a pilot study to a planned PO1 submission
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Able to tolerate a PET/CT scan
- •Age of 18 or older
- •signed informed consent
- •being considered for radiotherapy for treatment of CNS mets, Head and neck cancer, lung cancer, prostate cancer or esophageal cancer
排除标准
- •Prior XRT to site being studied
- •severe claustrophobia or inability to tolerate PET/CT
- •unable to provide written consent
- •pregnant or breastfeeding women
研究组 & 干预措施
2. Head and neck
Imaging with 18F-FLT PET
干预措施: Imaging with 18F-FLT PET (Procedure)
3. Lung
Imaging with 18F-FLT PET
干预措施: Imaging with 18F-FLT PET (Procedure)
4. prostate
Imaging with 18F-FLT PET
干预措施: Imaging with 18F-FLT PET (Procedure)
5. esophagus
Imaging with 18F-FLT PET
干预措施: Imaging with 18F-FLT PET (Procedure)
1.CNS
Imaging with 18F-FLT PET
干预措施: Imaging with 18F-FLT PET (Procedure)
结局指标
主要结局
To test whether the cellular response to fractionated radiotherapy leads to observable global change in the uptake of 18F-FLT as assessed by PET imaging
时间窗: end of study
次要结局
- To assess the technical and logistic feasibility of 18F-FLT scans in a population of cancer patients(end of study)