Elderly Patients and COVID-19 Infection: a Cohort of Fifty Patients Over Ninety Years of Age
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Demographic data
研究概览
简要总结
SARS-CoV2 or CoVid19 disease is a newly described pathology linked to a subtype of the coronavirus family identified in China in December 2019. This pathology can present multiple clinical facets, ranging from asymptomatic forms to more commonly critical pulmonary forms called "Acute Respiratory Distress Syndrome". The elderly population is more at risk for this infection due to the senescence of the immune system, co-morbidities and poly medications. They also often present a greater state of fragility.
This study aims to report the epidemiology of the first 50 patients over 90 years of age hospitalized within the CHU Brugmann hospital.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 90 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Be over 90 years of age on the date of admission to CHU Brugmann Hospital
- •Have a SARS Cov2 infection proven by antigen or RT-PCR on smear and / or typical imaging regardless of the clinical manifestation
- •Have been hospitalized at CHU Brugmann between 03/01/2020 and 05/10/2020
排除标准
- 未提供
结局指标
主要结局
Demographic data
时间窗: 5 minutes
Age, sex, ethnicity
CK
时间窗: 5 minutes
CK at hospital admission or first recorded
Troponin
时间窗: 5 minutes
Troponin at hospital admission or first recorded
Number of pulmonary lobes affected
时间窗: 5 minutes
Number of pulmonary lobes affected
Comorbidities
时间窗: 5 minutes
Smoking, Obesity, Diabetes, Arterial hypertension, Coronary pathology, Cerebrovascular disease, chronic renal failure, chronic obstructive pulmonary disease, Neoplasia, Autoimmune disease, Chronic liver disease
Gasometry
时间窗: 5 minutes
Vital signs at hospital admission: Gasometry
Blood count
时间窗: 5 minutes
Blood count at hospital admission or first recorded
Coagulation
时间窗: 5 minutes
Coagulation at hospital admission or first recorded
Renal function
时间窗: 5 minutes
Renal function at hospital admission or first recorded
Albumin
时间窗: 5 minutes
Albumin at hospital admission or first recorded
Ionogram
时间窗: 5 minutes
Ionogram at hospital admission or first recorded
NTproBNP
时间窗: 5 minutes
NTproBNP at hospital admission or first recorded
Length of ICU Stay
时间窗: 5 minutes
Length of ICU Stay
Procalcitonin
时间窗: 5 minutes
Procalcitonin at hospital admission or first recorded
Treatments
时间窗: 5 minutes
Under Chronic corticosteroid therapy or Immunosuppressive therapy
Hypotension
时间窗: 5 minutes
Vital signs at hospital admission: Hypotension
Infectious data
时间窗: 5 minutes
Contact with confirmed covid person before admission, lives in a retirement home with other cases, Initial bacterial or viral co-infection, Bacterial or viral co-infection during the hospital stay
D-dimers at hospital admission or first recorded
时间窗: 5 minutes
D-dimers
Status at hospital exit
时间窗: 5 minutes
One of the following choices: death, went back home, went back to a retirement home, was placed in a revalidation unit.
Treatment received
时间窗: 5 minutes
Hydroxychloroquine or Azithromycin
Liver function
时间窗: 5 minutes
Liver function at hospital admission or first recorded
Fibrinogen
时间窗: 5 minutes
Fibrinogen at hospital admission or first recorded
Fever
时间窗: 5 minutes
Vital signs at hospital admission: Fever
Hypoxemia
时间窗: 5 minutes
Vital signs at hospital admission: Hypoxemia
Tachycardia
时间窗: 5 minutes
Vital signs at hospital admission:Tachycardia
Mortality
时间窗: 5 minutes
28-day mortality after PCR / CT scan / diagnosis
Cumulative Illness Rating Scale-Geriatric (CIRS-G)
时间窗: 5 minutes
CIRS-G quantifies burden of disease in elderly patients (comorbidity scale). Higher scores indicate higher severity (maximum score = 56 points).
Signs and symptoms
时间窗: 5 minutes
Presence and date of first apparition: Fever, Cough, Dyspnea, Chest pain, Nausea or vomiting, Diarrhea, Fatigue, Anosmia, ageusia, inappetence, Confusion, Fall, Fracture
CRP
时间窗: 5 minutes
CRP at hospital admission or first recorded
Ferritin
时间窗: 5 minutes
Ferritin at hospital admission or first recorded
Biology - highest rate
时间窗: 5 minutes
Highest rate of CRP, D-Dimers, Urea, Creatinin, Fibrinogen, CK, Troponins
Biology - lowest rate
时间窗: 5 minutes
Lowest rate of hemoglobin, platelets, leucocytes, lymphocytes, albumin, Na+, K+
Percentage of pulmonary involvement on chest CT scan
时间窗: 5 minutes
Percentage of pulmonary involvement on chest CT scan
Type of lesions
时间窗: 5 minutes
Type of lesions as reflected on the CT scan images: 'Ground glass' or 'Crazy paving'
Need for oxygenotherapy
时间窗: 5 minutes
Need for oxygenotherapy (yes/no)
Means of ventilation
时间窗: 5 minutes
Means of ventilation
次要结局
未报告次要终点
研究者
Murielle Surquin
Head of geriatry department
Brugmann University Hospital