Pain Perception in Suicidal Behavior Vulnerability
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 167
- 试验地点
- 2
- 主要终点
- Pain tolerance reported by the patient
研究概览
简要总结
In France, almost 1 death on 50 is a suicide. The suicide occurs in unbearable psychic pain where mental trouble has a major influence. It is classified as preventable mortality. According to interpersonal psychological theory of suicide, the repeated exposition to stressful and painful events (as physical abuse) would facilitate suicide attempt through the increased pain tolerance. The social pain (or psychical pain on the broader sense) and physical pain are closely linked.
The investigators hypothesize that the measure of painful perception will be significantly superior on suicidals attempters compared to non-attempters. It will be the case for recent suicide attempters and former suicide attempters, suggesting a suicidal vulnerability trait. Moreover, the investigators expect that social distress induced by a social exclusion paradigm will be significantly superior on suicide attempters compared to non-attempters.
The aim of the study is to investigate the physical and psychic pain on depressed subjects with or without history of suicide attempts.
After a clinical evaluation (psychiatric symptomatology, personality trait, suicidal dimension), subjects will be submitted to a painful thermic stimulation and will participate at a computer test of social exclusion (named Cyberball).
详细描述
242 depressed patients ( 81 recent suicide attempters, 81 former suicide attempters, 80 non-attempters)
First visit : clinical assessment Second visit : pain evaluation and blood sample (from one day to a week maximum after the first visit).
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Pain tolerance reported by the patient
时间窗: During thermal stimulation
temperature measured when the subject will perceive as intolerable the pain following a painful stimulation performed using a thermode
次要结局
- Social distress perception assessed by social distress questionnaire(At V2 (one week maximum after the inclusion))
- Measure of cardiac frequency in response to thermal pain(At V2 (one week maximum after the inclusion))
- Kinetics of pain intensity(During thermal stimulation performed at the inclusion)
- Social distress perception assessed by the Rejection Sensitivity Questionnaire (RSQ)(At the inclusion)
- Pain intensity reported by the patient(During thermal stimulation)
- Pain threshold reported by the patient(During thermal stimulation)
- Temperature assessed at 4/10 on likert scale(During thermal stimulation performed at the inclusion)
- Social rejection sensitivity assessed by the Rejection Sensitivity Questionnaire (RSQ)(At the inclusion)
- Psychological pain intensity(At V2 (one week maximum after the inclusion))