Evaluation of Cardio-pulmonary, Physcial and Neuro-psychiatric Function in Patients Who Survived a Therapy-refractory Cardiac Arrest With Extracorporeal Cardiopulmonary Resuscitation.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Left ventricular ejection fraction (LVEF)
研究概览
简要总结
A cardiac arrest event has severe impact on the patient´s health-related quality of life. Survival of cardiac arrest does not innately translate to favorable quality of life. In particular, highly invasive resuscitation strategies, including extracorporeal cardio-pulmonary resuscitation (ECPR) due to therapy-refractory cardiac arrest, may have impact on long-term outcomes. Therefore, apart from acute medical treatment and physical rehabilitation, long-term effects on cardio-pulmonary, physical and neuro-psychiatric functions after cardiac arrest survival have to be evaluated and optimized. We plan to investigate a bundle of cardio-pulmonary, physical and neuro-psychiatric functions in patients who survived a therapy-refratory cardiac arrest with ECPR.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients
- •Survival of cardiac arrest
- •Use of extracorporeal cardiopulmonary resuscitation (ECPR) with veno-arterial extracorporeal membrane oxygenation (VA-ECMO) or ECMELLA (VA-ECMO and left-ventricular Impella micro-axial pump)
排除标准
- •Non-adult patients
- •No cardiac arrest
- •No use of ECPR
- •Inability to comply with follow-up
结局指标
主要结局
Left ventricular ejection fraction (LVEF)
时间窗: LVEF witihin one year after index cardiac arrest event.
LVEF measured with transthoracic echocardiography.
次要结局
- Vital function: Blood pressure(Blood pressure witihin one year after index cardiac arrest event.)
- Vital function: Peripheral oxygen saturation(Peripheral oxygen saturation witihin one year after index cardiac arrest event.)
- Vital function: Electrocardiogram (ECG)(ECG activity witihin one year after index cardiac arrest event.)
- Cognitive function(Cognitive function witihin one year after index cardiac arrest event.)
- Sign and symptoms of heart failure(Sign and symptoms of heart failure witihin one year after index cardiac arrest event.)
- Activity of daily living (ADL)(ADL witihin one year after index cardiac arrest event.)
- Comorbidity level(Comorbidity level witihin one year after index cardiac arrest event.)
- Number of cardiovascular medications(Number of cardiovascular medication witihin one year after index cardiac arrest event.)
- Cardiac stress test: Ergometry(Physical function witihin one year after index cardiac arrest event.)
- Cardiac stress test: Walking distance(Physical function witihin one year after index cardiac arrest event.)
研究者
Tharusan Thevathasan
Principal Investigator
Charite University, Berlin, Germany