NCT02992002已完成不适用
Influence of Fluid Challenge on End-Expiratory Lung Impedance in Mechanically Ventilated Patients Monitored With Electrical Impedance Tomography
University Hospital Schleswig-Holstein1 个研究点 分布在 1 个国家目标入组 25 人开始时间: 2016年12月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- Change in end-expiratory lung impedance (EELI)
研究概览
简要总结
The study investigates the influence of a clinically indicated fluid challenge on end-expiratory lung impedance, assessed by electrical impedance tomography (EIT). EIT data will be collected before, during and after infusion of 500 ml of crystalloid solution in mechanically ventilated patients on an operative intensive care unit.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients on mechanical ventilation
- •clincial decision to monitor regional ventilation with electrical impedance tomography
- •clinical indication for fluid challenge
- •established cardiac output monitoring with transpulmonary thermodilution
排除标准
- •age < 18 years
- •open lung injuries
- •instable injury of spine or cranium
- •thoracic metal implants
- •body mass index > 35
结局指标
主要结局
Change in end-expiratory lung impedance (EELI)
时间窗: 15-30 minutes
To assess the effect of fluid challenge on EELI, the change in EELI during the fluid challenge will be measured by electrical impedance tomography and will be compared to the change in EELI during the last 15 minutes before start of the fluid challenge.
次要结局
- Correlation between change in end-expiratory lung impedance and change in intrathoracic blood volume(15-30 minutes)
- Fluid responsiveness(15-30 minutes)
研究者
Tobias Becher
Dr Tobias Becher
University Hospital Schleswig-Holstein
研究点 (1)
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