NCT01346891已完成不适用
Polymorphisms of the Thiazide's Receptor Gene SLC12A3 and Development of Hyponatremia
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
研究概览
简要总结
The purpose of this study is to detect if there are any differences in the coding region of SLC12A3 gene in individuals who have had hyponatremia associated to the use of thiazides, and those thiazides consumers without hyponatremia that have demonstrated good tolerance to the drug.
详细描述
This is a Case Control study to compare the coding region of SLC12A3 gene in individuals who have had hyponatremia associated to the use of thiazides, and those thiazides consumers without hyponatremia that have demonstrated good tolerance to the drug.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 21 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients older than 21 years, belonging to one of the following groups:
- •Patients who have had Thiazide induced hyponatremia with serum sodium lower than 125 meq/L included in the Institutional Registry of Hyponatremia (Cases)
- •Patients with good tolerance to chronic treatment with Thiazides tha never had associated hyponatremia (Controls)
- •Patients with normal serum sodium measurements before the start of the Thiazides
排除标准
- •Refusal to participate or to the informed consent process
- •Unclear cause of hyponatremia, or other hyponatremia cause concomitant to Thiazide diuretics
- •Patients related to other individuals already included in the study
研究者
研究点 (1)
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