Bupropion Versus Placebo in the Treatment of Pathological Gambling
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 1
研究概览
简要总结
This study will determine whether the drug bupropion is an effective treatment for Pathological Gambling.
详细描述
As gambling opportunities proliferate, PG has become a major health concern. Despite its importance, few treatment options with proven efficacy exist. This study will attempt to identify an effective treatment for PG.
Participants are randomly assigned to receive either bupropion or placebo for 12 weeks. Participants are assessed at baseline and at Weeks 2, 3, 4, 5, 6, 8, 10, and 12. Self administered questionnaires and interviews are used to assess participants. Follow-up assessments are made 1, 3, and 6 months after study completion.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Meet the criteria for Pathological Gambling (DSM-IV-TR), through the administration of the National Opinion Research Center DSM Screen for Gambling Problems(NODS);
- •Meet the criteria for Pathological Gambling (DSM-IV-TR), through the administration of the National Opinion Research Center DSM Screen for Gambling Problems(NODS);
- •Receive a score of 5 or more on the South Oaks Gambling Screen (SOGS);
- •Have PG for at least one year;
- •Have had at least 2 or more gambling episodes during the 2-week screening period;
- •Speak standard English;
- •Be able to give written informed consent.
排除标准
- •Evidence of current (past 3 months) substance misuse;
- •Had a Hamilton Depression Rating Scale (HDRS)27 score of 18 or more (or a score on item 1 of greater than 2;
- •Had a current eating disorder (except binge eating disorder);
- •Had any history of seizures, or suicidal or aggressive behavior;
- •Had a urine drug screen positive for stimulants, opiates, hallucinogens, or phencyclidine;
- •Had a current or past psychotic disorder, bipolar disorder, or significant cognitive disorder;
- •Received monoamine oxidase inhibitors within 3 weeks of randomization, long acting phenothiazine within 3 months of randomization,fluoxetine within 4 weeks of randomization, or other psychotropic drugs within 2 weeks of randomization;
- •Had prior exposure to bupropion;
- •Were engaged in individual, group, or couples psychotherapy during the 2 weeks before randomization, (except Gamblers Anonymous).
研究组 & 干预措施
Subjects receivng Bupropion
The active arm subjects in this study (n = 18) received flexibly dosed bupropion in this randomized 12-week double-blind trial.
干预措施: Bupropion (Drug)
Subjects receiving Placebo
The inactive arm subjects in this randomly controlled study (n = 21) received a placebo.
干预措施: Placebo (Drug)
研究者
Donald Black
Professor of and MD in Psychiatry
University of Iowa