Comparative Study Between Ondansetron, Isopropyl Alcohol Inhalation and Super Hydration in Treatment of Postoperative Emesis After Laparoscopic Appendectomy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 240
- 试验地点
- 1
- 主要终点
- numbers of vomiting attacks
研究概览
简要总结
To compare and evaluate the antiemetic effect and the safety of ondansetron, inhalational isopropyl alcohol and super hydration on adult patients after laparoscopic appendectomy.
详细描述
This prospective double-blind study done on 240 patients admitted to surgical I.C.U after laparoscopic appendectomy. Those who had preoperative Koivuranta vomiting score of more than 3 enrolled in our study. Every group contains 80 patients. Patients of group A received ondansetron 4 mg intravenous immediately once reached to I.C.U and another same dose after 6 hours while patients of group B received isopropyl alcohol 70% inhalation every 15 min for 4 times then repeated after 6 hours. The last group C received intravenous normal saline at rate of 20 ml/kg over 30 minute and repeated by the same dose after 6 hours. The duration of the study was 24 hours post-operatively. As PONV is self-limited within 24 hours.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •postoperative nausea and vomiting
排除标准
- •systemic disease as diabetes or hypertension local gastric diseases
研究组 & 干预措施
Group B
received isopropyl alcohol 70% inhalation every 15 min for 4 times then repeated after 6 hours
干预措施: laparoscopic appendectomy (Procedure)
Group A
received ondansetron 4 mg intravenous immediately once reached to I.C.U and another same dose after 6 hours
干预措施: Ondansetron (Drug)
Group A
received ondansetron 4 mg intravenous immediately once reached to I.C.U and another same dose after 6 hours
干预措施: laparoscopic appendectomy (Procedure)
Group B
received isopropyl alcohol 70% inhalation every 15 min for 4 times then repeated after 6 hours
干预措施: isopropyl alcohol 70% inhalation (Drug)
Group C
received intravenous normal saline at rate of 20 ml/kg over 30 minute and repeated by the same dose after 6 hours.
干预措施: laparoscopic appendectomy (Procedure)
结局指标
主要结局
numbers of vomiting attacks
时间窗: for one day
numbers of vomiting attacks recorded every 15 minutes for one day
次要结局
未报告次要终点