Role of the Neurovascular System in Spontaneous Coronary Artery Dissection (SCAD)
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- Mayo Clinic
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- Arterial stiffness
研究概览
简要总结
The purpose of this research is to compare sympathetic function (flight or fight system) and arterial health including structure and mechanics of participants with history of spontaneous coronary artery dissection (SCAD) to age and sex matched control participants.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Health Services Research
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •For SCAD patients: history of SCAD as confirmed by coronary angiography or cardiac computed tomography angiography
- •For controls: no cardiac disease history
排除标准
- •Pregnancy
- •Known or suspected unstable cardiac condition within 4 weeks of the study
- •Active treatment with anticoagulation or dual antiplatelet therapy
研究组 & 干预措施
Spontaneous coronary artery dissection (SCAD) group
Subject with a history of SCAD will undergo a series of diagnostic studies to assess neurovascular function.
干预措施: Carotid Ultrasounds (Diagnostic Test)
Spontaneous coronary artery dissection (SCAD) group
Subject with a history of SCAD will undergo a series of diagnostic studies to assess neurovascular function.
干预措施: Elastography (Diagnostic Test)
Spontaneous coronary artery dissection (SCAD) group
Subject with a history of SCAD will undergo a series of diagnostic studies to assess neurovascular function.
干预措施: Arterial Tonometry (Other)
Spontaneous coronary artery dissection (SCAD) group
Subject with a history of SCAD will undergo a series of diagnostic studies to assess neurovascular function.
干预措施: Echocardiogram (Diagnostic Test)
Spontaneous coronary artery dissection (SCAD) group
Subject with a history of SCAD will undergo a series of diagnostic studies to assess neurovascular function.
干预措施: Ankle-Brachial Index (Other)
Spontaneous coronary artery dissection (SCAD) group
Subject with a history of SCAD will undergo a series of diagnostic studies to assess neurovascular function.
干预措施: Microneurography with sympathoexcitatory maneuvers (Other)
Healthy Control Group
Healthy subjects will undergo a series of diagnostic studies to assess neurovascular function.
干预措施: Arterial Tonometry (Other)
Healthy Control Group
Healthy subjects will undergo a series of diagnostic studies to assess neurovascular function.
干预措施: Echocardiogram (Diagnostic Test)
Healthy Control Group
Healthy subjects will undergo a series of diagnostic studies to assess neurovascular function.
干预措施: Carotid Ultrasounds (Diagnostic Test)
Healthy Control Group
Healthy subjects will undergo a series of diagnostic studies to assess neurovascular function.
干预措施: Elastography (Diagnostic Test)
Healthy Control Group
Healthy subjects will undergo a series of diagnostic studies to assess neurovascular function.
干预措施: Ankle-Brachial Index (Other)
Healthy Control Group
Healthy subjects will undergo a series of diagnostic studies to assess neurovascular function.
干预措施: Microneurography with sympathoexcitatory maneuvers (Other)
结局指标
主要结局
Arterial stiffness
时间窗: Baseline
Measured by carotid ultrasound pulse wave velocity reporting in m/s
Sympathetic response to stress
时间窗: Baseline
Blood pressure or muscle sympathetic nerve activity response to sympathoexcitatory stressors (mm/Hg or bursts/min).
Arterial thickness
时间窗: Baseline
Measured by carotid ultrasound intimal media thickness reporting in mm
Baroreflex sensitivity
时间窗: Baseline
The slope between heart rate and blood pressure at rest and during the Valsalva Maneuver (ms/mmHg)
次要结局
未报告次要终点
研究者
Marysia Tweet
Principal Investigator
Mayo Clinic