Incidence of Postoperative Diaphragmatic Dysfunction in Pregnant Women With Preeclampsia With Severe Features Undergoing Cesarean Delivery: A Prospective Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 52
- 试验地点
- 1
- 主要终点
- The incidence of postoperative diaphragmatic dysfunction
研究概览
简要总结
Preeclampsia with severe features remains a leading contributor to maternal morbidity and mortality, particularly in low- and middle-income countries. It is defined by hypertension and involvement of multiple organ systems, including renal, hepatic, hematologic, and neurologic pathways. The interplay of endothelial dysfunction, capillary leakage, and disrupted fluid balance in these patients increases their susceptibility to perioperative pulmonary complications. Although respiratory complications in preeclampsia are clinically significant, the true incidence of postoperative diaphragmatic dysfunction in women with severe disease is not well established. Existing literature largely emphasizes general respiratory failure, pulmonary edema, or the need for mechanical ventilation, rather than specifically evaluating diaphragmatic performance with objective methods such as ultrasound. The current study sought to determine the incidence and identify risk factors for postoperative diaphragmatic dysfunction in women with severe preeclampsia following cesarean delivery.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 40 Years(Adult)
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Patients with severe preeclampsia undergoing cesarean section
- •Gestational age > 32 weeks
排除标准
- •• Age < 20 years.
- •Patients with neuromuscular diseases.
- •Patient refusal.
- •Contraindications to magnesium sulphate administration
- •Inability to obtain adequate ultrasound views
研究组 & 干预措施
Preeclampsia with severe features
diaphragmatic excursion evaluation
结局指标
主要结局
The incidence of postoperative diaphragmatic dysfunction
时间窗: Diaphragmatic excursion is measured before and 24 hours after surgery.
diaphragmatic dysfunction is defined as a mean diaphragmatic excursion of less than 10 mm
次要结局
- Percentage of change in DE(24 hours after surgery)
- Risk factors associated with postoperative diaphragmatic dysfunction(24 hours after surgery)
