Assessment of Glucocorticoid Receptor Gene Polymorphism in Alopecia Areata
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Distribution of NR3C1 rs41423247 Genotypes and Alleles
研究概览
简要总结
Alopecia areata is an autoimmune, non-scarring hair loss disorder with multifactorial pathogenesis. The glucocorticoid receptor gene (NR3C1) plays an essential role in immune regulation and inflammatory response. The rs41423247 polymorphism (BclI) may influence glucocorticoid sensitivity and disease activity. This study aims to investigate the association between NR3C1 rs41423247 polymorphism and susceptibility to alopecia areata and to evaluate its correlation with disease severity using the Severity of Alopecia Tool (SALT) score.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Clinically diagnosed alopecia areata
- •Age ≥ 18 years
- •Both sexes
- •Willingness to participate and provide informed consent
- •Inclusion Criteria (Controls):
- •Apparently healthy individuals
- •No history of autoimmune disease
- •Age- and sex-matched to cases
- •Provided informed consent
排除标准
- •Presence of other autoimmune or inflammatory diseases
- •Current systemic immunosuppressive therapy
- •Pregnancy or lactation
- •Refusal to participate
研究组 & 干预措施
Group 1: Alopecia Areata Patients
Participants diagnosed clinically with alopecia areata (n = 60). Peripheral blood samples will be collected for genetic analysis of NR3C1 rs41423247 polymorphism. Disease severity will be assessed using SALT score.
Group 2: Healthy Controls
Age- and sex-matched healthy individuals without autoimmune disease (n = 60). Peripheral blood samples will be collected for genetic analysis of NR3C1 rs41423247 polymorphism.
结局指标
主要结局
Distribution of NR3C1 rs41423247 Genotypes and Alleles
时间窗: Baseline
Comparison of genotype and allele frequencies of NR3C1 rs41423247 polymorphism between alopecia areata patients and healthy controls.
次要结局
- Association Between NR3C1 rs41423247 Polymorphism and Disease Severity(Baseline)
研究者
karem Taha ibrahim khalil
assistant professor
Benha University