NCT02509000已完成不适用
Beijing Indoor Air Purifier Intervention Study
WeiHuang0 个研究点目标入组 35 人开始时间: 2013年12月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 35
- 主要终点
- respiratory inflammation
研究概览
简要总结
This study aimed to assess the impact of air filtration on indoor air quality and cardio-pulmonary health in residents living in high outdoor pollution settings in Beijing.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Health Services Research
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 40 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Global Initiative for Chronic Obstructive Lung Disease criteria (mild to moderate, GOLD stage I~II;
- •severe to very severe, GOLD stage III~IV) quit smoking for at least 1 year;
- •a ratio of pre-bronchodilator forced expiratory volume in one second (FEV1) to forced vital capacity (FVC) equal to or less than 0.70 and an increase of FEV1 with the use of 400μg of albuterol of less than 12% of the pre-bronchodilator one;
- •no history of asthma or any other active lung disease.
- •Subjects were free from exacerbations for at least 6 weeks.
排除标准
- •Patients with heart pacemaker,
- •heart failure with bundle-branch block,
- •recent myocardial infarction (in the last 12 weeks) and
- •anticoagulant therapy
结局指标
主要结局
respiratory inflammation
时间窗: 4 weeks
analyzed EBC pH and inflammation biomarkers 8-isoprostane and nitrite and nitrate
次要结局
- oxidative stress(4 weeks)
- systemic inflammation(4 weeks)
研究者
WeiHuang
Peking University School of Public Health
Peking University
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