Evaluation of Acquired and Hereditary Risk Factors of Neonatal Thrombosis: Single-centre Experience
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 11
- 主要终点
- Hereditary thrombophilia factors also should be thought
研究概览
简要总结
The incidence of symptomatic thrombosis is between 2.4 and 6.8 per 1000 neonatal intensive care unit admission while it is 5.1 per 100 000 live births. Compared to adults, the anticoagulant and fibrinolytic system of newborns is significantly different.
In this study, the aim is to evaluate infants with neonatal thrombosis in our unit to characterize acquired and genetic risk factors, the laboratory work-up parameters and the diagnosis approach.
详细描述
All newborn patients diagnosed with neonatal thrombosis in our NICU between 2014 and 2019; were included in the study.
Patients' data: maternal and neonatal characteristics, consanguinity, need for resuscitation, Apgar scores, diagnoses, need for mechanical ventilation, sepsis, catheter placement, treatment regimens and hospital outcomes; Laboratory findings: CBC; D-dimer levels and the performed genetic test Thrombosis diagnosis was confirmed by imaging techniques such as ultrasonography (USG), echocardiography, and magnetic resonance imaging (MRI).
The genotypes: Factor V (Leiden) G1691A, prothrombin G20210A, MTHFRC677T, MTHFRA1298C, PAI-SERPINE1, Factor XIII V34L mutations
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 1 Day 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All newborn accepted at NICU
排除标准
- 未提供
结局指标
主要结局
Hereditary thrombophilia factors also should be thought
时间窗: January 2022
Thrombosis in the neonatal period is multifactorial
时间窗: January 2022
次要结局
未报告次要终点
研究者
Nilufer Guzoglu
Assoc. Prof
Kırıkkale University