Effects of Age, Fitness Level, and Modality on Physiological Response to Acute Exercise
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 35
- 试验地点
- 2
- 主要终点
- Circulating relative and absolute counts of T cell subsets
研究概览
简要总结
The purpose of this study is to determine the effect of age and fitness level on the physiological response to an acute bout of resistance or aerobic exercise.
详细描述
Young and middle-aged to older adults who are physically active or not physically active will participate in two moderate to vigorous intensity exercise bouts: aerobic exercise and resistance training exercise. Blood will be collected to assess immune function and metabolism.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •"Young" Adults: ages 18-30
- •"Older" Adults: ages 55-75 and if a female postmenopausal
- •Participants classified as "trained" must participate in at least 30 minutes of moderate to vigorous intensity cardiovascular activity at least 3 days per week and engage in resistance training for all of the major muscle groups approximately 2 days / week. They must have upheld this activity for the past 3 months
- •Participants classified as "untrained" must be participating in less than 30 minutes of moderate to vigorous intensity cardiovascular activity and less than 2 days of resistance training per week for at least the last 3 months.
排除标准
- •Have any contraindications to moderate to vigorous exercise
- •Range of motion restrictions that would prevent them from participating in aerobic or resistance training with proper form (they must be ambulatory)
- •aking medications (prescription or over the counter) known to influence immune function, including daily NSAID's, beta blockers, statins, bisphosphonates, or steroids.
- •Have known cardiovascular, respiratory, metabolic, or renal disease, with the exception of controlled hypertension (as defined by resting BP below 140/90) and/or controlled asthma (self-reported).
- •Be pregnant
- •Be unable to complete all visits (i.e. must not be planning to leave the Houston area long-term before concluding their participation in the study which will span several weeks)
- •Fall outside of a BMI range of (18.5 - 30)
- •Consume alcohol or recreational drugs for 24h prior to visits
- •Older women cannot be pre-menopausal (must have not had a menses for at least 12 months)
- •Unable to speak or read English
- •Participants must not have scheduling conflicts that would prevent them from reporting to the laboratory of integrated physiology 4 times over the course of the study
结局指标
主要结局
Circulating relative and absolute counts of T cell subsets
时间窗: compare 1hr post-RT to 1hr post-AT
Flow cytometry to identify T cell subsets
Monocyte subset and function
时间窗: compare 1hr post-RT to 1hr post-AT
Flow cytometry to classify monocyte subsets and in vitro LPS stimulation to assess monocyte function
NK cell function
时间窗: compare 1hr post-RT to 1hr post-AT
Flow cytometry to identify NK cells and in vitro activity to assess NK activity
次要结局
- Serum cortisol(compare 1hr post-RT to 1hr post-AT)
研究者
Melissa M Markofski
Assistant Professor
University of Houston