NCT04173104已完成早期 1 期
Pilot Study of [18F]PARPi PET/MR Imaging in Patients With New and/or Suspected Recurrent Brain Tumors
适应症
干预措施
相关药物
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 入组人数
- 5
- 试验地点
- 1
- 主要终点
- SUVmax measurements
研究概览
简要总结
This study is to collect data about how 18FPARPi can be used together with PET/positron emission tomography and MRI/magnetic resonance imaging scans to take pictures of brain cancer
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with new or suspected recurrent brain tumors (including suspected recurrent brain tumors showing growth from any preceding scan)
- •Age >/= 18 years
- •Minimum at least one brain lesion size >/= 1.5cm diameter
- •Scheduled to undergo treatment at MSK
- •Willingness to sign informed consent
- •Able to receive intravenous gadolinium contrast per MSK Department of Radiology guidelines
排除标准
- •Any contraindication to 3T MRI (PET/MR scanner is 4.0 Tesla)
- •Pregnancy or breast-feeding women
研究组 & 干预措施
Participants with Brain Cancer
Experimental
Participants with new or suspected recurrent brain tumors
干预措施: PET/MR with [18F]PARPi (Diagnostic Test)
Participants with Brain Cancer
Experimental
Participants with new or suspected recurrent brain tumors
干预措施: [18F]PARPi (Drug)
结局指标
主要结局
SUVmax measurements
时间窗: Up to 24 weeks
\[18F\]PARPi updtake in lesions will be quantified by standard SUVmax measurements from PET/MR scans
次要结局
未报告次要终点
研究者
研究点 (1)
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