NCT01888055撤回不适用
Influence of Transcranial Direct-current Stimulation on Cortical Plasticity in Healthy Older Adults
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) in healthy older adults
研究概览
简要总结
The aim of this study is to investigate whether the anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) in healthy older adults leads to an increase in cortical plasticity (change in motor evoked potentials (MEP) in mV).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 50 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •right-handed according to the Oldfield Händigkeits inventory (lateralization index >70)(1971)
- •no obvious cognitive impairment (MMSE>26, Demtect>13)
- •age between 50 and 80 years
排除标准
- •Severe neurological / psychiatric or pre-existing internist conditions because additional cognitive deficits are expected
- •Epilepsy, epileptic seizure in medical history
- •Cognitive deficit (MMSE <20)
- •Depressive episode (Beck Depression Inventory (BDI) > 12)
- •intake of centrally active drugs <3 months , particularly acetylcholinesterase inhibitors
- •Pregnancy
- •Pacemaker (contraindication for MRI)
- •Other metal parts in the body (contraindication for MRI)
研究组 & 干预措施
transcranial direct current stimulation
Experimental
干预措施: transcranial direct current stimulation (Device)
sham stimulation
Placebo Comparator
干预措施: sham stimulation (Device)
结局指标
主要结局
anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) in healthy older adults
时间窗: 1 week
to investigate whether the anodal transcranial direct current stimulation over the primary motor cortex (M1) in healthy older adults increases cortical plasticity (measured via motor evoked potentials)compared to sham stimulation
次要结局
- Comparison of tDCS-induced changes in the learning success(1 week)
- Comparison of tDCS-induced changes on central cholinergic activity(1 week)
- genetic polymorphism, ApoE4(once)
- MR elastography(1 week)
研究者
Agnes Flöel
Prof. Dr.
Charite University, Berlin, Germany
研究点 (1)
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